Tbio WDR45 WD repeat domain phosphoinositide-interacting protein 4

Protein Summary

Description

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066). This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y484
• A6NGH5
• B7WPI2
• Q5MNZ5
• Q6IBS7
• Q6NT94
• Q96H03
• WIPI-4

Gene Name

• WDR45

Ensembl ID

• ENST00000322995
• ENSP00000365543
• ENSG00000196998
• ENST00000356463
• ENSP00000348848
• ENST00000376368
• ENSP00000365546
• ENST00000376372
• ENSP00000365551
• ENST00000634944
• ENSP00000488972

Symbol

• WDRX1
• WDRXI4
• WIPI4
• JM5
• NBIA4
• NBIA5
• WDRX1
• WIPI4
• WIPI-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
virus perturbation	0.98
histone modification site profile	0.91
transcription factor	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.94   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.94   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0