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Tbio
WDR45
WD repeat domain phosphoinositide-interacting protein 4

Protein Summary
Description
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066). This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322995
  • ENSP00000365543
  • ENSG00000196998
  • ENST00000356463
  • ENSP00000348848
  • ENST00000376368
  • ENSP00000365546
  • ENST00000376372
  • ENSP00000365551
  • ENST00000634944
  • ENSP00000488972

Symbol
  • WDRX1
  • WDRXI4
  • WIPI4
  • JM5
  • NBIA4
  • NBIA5
  • WDRX1
  • WIPI4
  • WIPI-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
0.98
histone modification site profile
0.91
transcription factor
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.13   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.13   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
p_int:  0.999994738
p_ni:  0.000005262
Score:  0.735
Data Source:  BioPlex,STRINGDB
ATG2B
Tbio
Novelty:  0.04963717
p_int:  0.999980009
p_ni:  0.000019991
Score:  0.947
Data Source:  BioPlex,STRINGDB
HDAC11
Tclin
Family:  Epigenetic
Novelty:  0.01015211
p_int:  0.994487228
p_ni:  0.005512767
p_wrong:  5e-9
Score:  0.552
Data Source:  BioPlex,STRINGDB
SPAST
Tbio
Novelty:  0.00303236
p_int:  0.983360113
p_ni:  0.016639606
p_wrong:  2.81e-7
Score:  0.254
Data Source:  BioPlex,STRINGDB
CISD1
Tchem
Novelty:  0.0118675
p_int:  0.974765444
p_ni:  0.013392842
p_wrong:  0.011841714
Data Source:  BioPlex
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
p_int:  0.958364201
p_ni:  0.040451262
p_wrong:  0.001184537
Score:  0.199
Data Source:  BioPlex,STRINGDB
SLC25A11
Tbio
Family:  Transporter
Novelty:  0.06125899
p_int:  0.955567654
p_ni:  0.044431627
p_wrong:  7.19e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
TALDO1
Tbio
Family:  Enzyme
Novelty:  0.00208619
p_int:  0.951364457
p_ni:  0.048265923
p_wrong:  0.00036962
Score:  0.719
Data Source:  BioPlex,STRINGDB
SALL2
Tbio
Family:  TF
Novelty:  0.01181421
p_int:  0.94555902
p_ni:  0.053025186
p_wrong:  0.001415794
Score:  0.547
Data Source:  BioPlex,STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.923156918
p_ni:  0.071830736
p_wrong:  0.005012346
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
56.2
mean platelet volume
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
56.2
mean platelet volume
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 45
715262
Mouse
MGI:1859606
54636
Rat
RGD:1359718
302559
Dog
WD repeat domain 45
VGNC:54611
612890
Horse
WD repeat domain 45
VGNC:49416
100052044
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 45
Mouse
Rat
Dog
WD repeat domain 45
Horse
WD repeat domain 45
Publication Statistics
PubMed Score 54.13
PubMed score by year
PubTator Score 48.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title