Tbio MTF2 Metal-response element-binding transcription factor 2

Protein Summary

Description

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

Uniprot Accession IDs

• Q9Y483
• A6NGQ9
• A8K2Q3
• B1AKT5
• B1AKT6
• Q96G26
• Q9UES9
• Q9UP40

Gene Name

• MTF2

Ensembl ID

• ENST00000370298
• ENSP00000359321
• ENSG00000143033
• ENST00000370303
• ENSP00000359326
• ENST00000540243
• ENSP00000443295
• ENST00000545708
• ENSP00000444962

Symbol

• PCL2
• M96
• PCL2
• TDRD19A
• dJ976O13.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
transcription factor binding site profile	0.98
protein domain	0.92
PubMedID	0.89

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Metal-response Element-binding Transcription Factor 2

DTO Classes

Protein / Nucleic Acid Binding / Metal-response Element-binding Transcription Factor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.76   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.76   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0