Tbio PRKAB1 5'-AMP-activated protein kinase subunit beta-1

Protein Summary

Description

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y478
• Q9UBV0
• Q9UE20
• Q9UEX2
• Q9Y6V8
• AMPK subunit beta-1

Gene Name

• PRKAB1

Ensembl ID

• ENST00000229328
• ENSP00000229328
• ENSG00000111725
• ENST00000541640
• ENSP00000441369

Symbol

• AMPK
• AMPK
• HAMPKb

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
drug perturbation	0.99
interacting protein	0.99
transcription factor binding site profile	0.96
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / 5'-amp-activated Protein Kinase Subunit Beta-1

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camkl Family / 5'-amp-activated Protein Kinase Subunit Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.58   (req: < 5)

Gene RIFs: 114   (req: <= 3)

Antibodies: 708   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.58   (req: >= 5)

Gene RIFs: 114   (req: > 3)

Antibodies: 708   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0