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Tbio
ZNF175
Zinc finger protein 175

Protein Summary
Description
Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262259
  • ENSP00000262259
  • ENSG00000105497

Symbol
  • OTK18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
cell line
0.66
transcription factor binding site profile
0.64
histone modification site profile
0.58
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.12   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.12   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
69.5
lymphocyte count
2
1
2
64.9
neutrophil percentage of leukocytes
1
1
1
59.5
eosinophil percentage of leukocytes
1
1
1
56.4
mean corpuscular volume
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
69.5
lymphocyte count
2
64.9
neutrophil percentage of leukocytes
1
59.5
eosinophil percentage of leukocytes
1
56.4
mean corpuscular volume
1
38.8
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 175
VGNC:2192
456251
Macaque
zinc finger protein 175
719973
Dog
zinc finger protein 175
VGNC:48667
100686614
Horse
zinc finger protein 175
VGNC:49297
100147677
Cow
zinc finger protein 175
VGNC:49992
537103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 175
Macaque
zinc finger protein 175
Dog
zinc finger protein 175
Horse
zinc finger protein 175
Cow
zinc finger protein 175
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y473-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (10)
1 – 10 of 10
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.938
Data Source:  STRINGDB
ZBTB3
Tdark
Family:  TF
Novelty:  0.34423886
Score:  0.719
Data Source:  STRINGDB
ZNF106
Tbio
Novelty:  0.17021565
Score:  0.493
Data Source:  STRINGDB
MRFAP1L1
Tdark
Novelty:  0.87470289
Score:  0.473
Data Source:  STRINGDB
EMC3
Tbio
Novelty:  0.01113829
Score:  0.458
Data Source:  STRINGDB
BATF2
Tbio
Family:  TF
Novelty:  0.04154227
Score:  0.431
Data Source:  STRINGDB
ZNF69
Tbio
Family:  TF
Novelty:  0.06324696
Score:  0.426
Data Source:  STRINGDB
PRLHR
Tchem
Family:  GPCR
Novelty:  0.05024441
Score:  0.405
Data Source:  STRINGDB
MYO7B
Tbio
Novelty:  0.10660261
Score:  0.402
Data Source:  STRINGDB
SIGLEC6
Tbio
Novelty:  0.06943962
Score:  0.4
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.12

PubMed score by year
PubTator Score  8.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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