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Tchem
L3MBTL1
Lethal(3)malignant brain tumor-like protein 1

Protein Summary
Description
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373135
  • ENSP00000362227
  • ENSG00000185513
  • ENST00000422861
  • ENSP00000410139
  • ENST00000427442
  • ENSP00000402107

Symbol
  • KIAA0681
  • L3MBT
  • L3MBTL
  • L3MBTL
  • ZC2HC3
  • H-L(3)MBT
  • dJ138B7.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
protein domain
0.73
molecular function
0.7
biological process
0.68
tissue sample
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.05   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.05   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2426365
chemical structure image
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
L3MBTL1, histone methyl-lysine binding protein
VGNC:14861
469947
Macaque
L3MBTL1, histone methyl-lysine binding protein
695694
Mouse
MGI:2676663
241764
Rat
RGD:1307316
311613
Dog
L3MBTL1, histone methyl-lysine binding protein
VGNC:54652
477231
Species
Name
OMA
EggNOG
Inparanoid
Chimp
L3MBTL1, histone methyl-lysine binding protein
Macaque
L3MBTL1, histone methyl-lysine binding protein
Mouse
Rat
Dog
L3MBTL1, histone methyl-lysine binding protein
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y468-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Methylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Methylation
Gene Ontology Terms (21)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (99)
1 – 10 of 99
ZNF644
Tbio
Family: TF
Novelty: 0.12816167
p_int: 0.999998335
p_ni: 0.000001665
Score: 0.161
Data Source: BioPlex,STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
p_int: 0.999998305
p_ni: 0.000001695
Data Source: BioPlex
SAMD11
Tdark
Novelty: 0.32977476
p_int: 0.999793874
p_ni: 0.000206126
Score: 0.181
Data Source: BioPlex,STRINGDB
FAM208B
Tdark
Novelty: 1.21420488
p_int: 0.999683843
p_ni: 0.000316157
Score: 0.181
Data Source: BioPlex,STRINGDB
WIZ
Tbio
Family: TF
Novelty: 0.04458547
p_int: 0.999637786
p_ni: 0.000362214
Score: 0.304
Data Source: BioPlex,STRINGDB
EHMT2
Tchem
Family: Epigenetic
Novelty: 0.00262578
p_int: 0.999421648
p_ni: 0.000578351
p_wrong: 1e-9
Score: 0.534
Data Source: BioPlex,STRINGDB
ZNF195
Tdark
Family: TF
Novelty: 0.23029736
p_int: 0.999178558
p_ni: 0.000821383
p_wrong: 5.9e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
ANAPC1
Tbio
Family: Enzyme
Novelty: 0.0521845
p_int: 0.998176417
p_ni: 0.001823583
Score: 0.151
Data Source: BioPlex,STRINGDB
EHMT1
Tchem
Family: Epigenetic
Novelty: 0.00821799
p_int: 0.99752907
p_ni: 0.00247093
Score: 0.48
Data Source: BioPlex,STRINGDB
CBX2
Tchem
Family: Epigenetic
Novelty: 0.01952928
p_int: 0.996972942
p_ni: 0.001899011
p_wrong: 0.001128046
Score: 0.392
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  43.05

PubMed score by year
PubTator Score  26.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer