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Tbio
NR2E1
Nuclear receptor subfamily 2 group E member 1

Protein Summary
Description
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368983
  • ENSP00000357979
  • ENSG00000112333
  • ENST00000368986
  • ENSP00000357982

Symbol
  • TLX
  • TLL
  • TLX
  • XTLL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.9
protein domain
0.73
PubMedID
0.62
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.73   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.73   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
36.9
alcohol consumption measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
36.9
alcohol consumption measurement
1
30.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group E member 1
VGNC:3597
472088
Macaque
nuclear receptor subfamily 2 group E member 1
701101
Mouse
MGI:1100526
21907
Rat
RGD:1595162
684085
Dog
nuclear receptor subfamily 2 group E member 1
VGNC:43949
475017
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group E member 1
Macaque
nuclear receptor subfamily 2 group E member 1
Mouse
Rat
Dog
nuclear receptor subfamily 2 group E member 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y466-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Intracellular signaling by second messengers
Reactome
Nuclear Receptor transcription pathway
Reactome
PIP3 activates AKT signaling
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Intracellular signaling by second messengers
Nuclear Receptor transcription pathway
PIP3 activates AKT signaling
Gene Ontology Terms (37)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (112)
1 – 10 of 112
DCAF6
Tbio
Novelty:  0.01269552
p_int:  0.999957053
p_ni:  0.000042947
Score:  0.168
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.990918889
p_ni:  0.009081111
Score:  0.199
Data Source:  BioPlex,STRINGDB
ARL10
Tdark
Family:  Enzyme
Novelty:  1.16329406
p_int:  0.984474958
p_ni:  0.015525042
Score:  0.181
Data Source:  BioPlex,STRINGDB
TNRC6C
Tbio
Novelty:  0.09764186
p_int:  0.97784577
p_ni:  0.02215423
Score:  0.205
Data Source:  BioPlex,STRINGDB
MTDH
Tbio
Novelty:  0.00342872
p_int:  0.931013378
p_ni:  0.068986622
Score:  0.239
Data Source:  BioPlex,STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.930198541
p_ni:  0.069801459
Data Source:  BioPlex
VRK3
Tbio
Family:  Kinase
Novelty:  0.15665279
p_int:  0.860306768
p_ni:  0.000175806
p_wrong:  0.139517426
Score:  0.199
Data Source:  BioPlex,STRINGDB
CIZ1
Tbio
Novelty:  0.03730538
p_int:  0.844312239
p_ni:  0.134148602
p_wrong:  0.021539159
Score:  0.188
Data Source:  BioPlex,STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.811471031
p_ni:  0.188528969
Data Source:  BioPlex
ATN1
Tbio
Novelty:  0.01227042
Score:  0.98
Data Source:  STRINGDB
Publication Statistics
PubMed Score  68.73

PubMed score by year
PubTator Score  22.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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