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Tchem
DYRK1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Protein Summary
Description
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323039
  • ENSP00000312789
  • ENSG00000105204
  • ENST00000348817
  • ENSP00000221803
  • ENST00000430012
  • ENSP00000403182
  • ENST00000593685
  • ENSP00000469863
  • ENST00000597639
  • ENSP00000472941
  • ENST00000625388
  • ENSP00000486839
  • ENSG00000281320
  • ENST00000625438
  • ENSP00000487313
  • ENST00000625757
  • ENSP00000485915
  • ENST00000627034
  • ENSP00000487539
  • ENST00000631090
  • ENSP00000486377

Symbol
  • MIRK
  • MIRK
  • AOMS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
small molecule
0.92
gene perturbation
0.74
protein domain
0.73
kinase perturbation
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.36   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.36   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 89
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (56)
CEFIP
Tdark
Novelty:  0.72318421
p_int:  0.999999972
p_ni:  2e-9
p_wrong:  2.6e-8
Score:  0.823
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999999895
p_ni:  1.01e-7
p_wrong:  4e-9
Data Source:  BioPlex
DCAF7
Tbio
Novelty:  0.02609518
p_int:  0.999999638
p_ni:  1.18e-7
p_wrong:  2.44e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
FAM117B
Tdark
Novelty:  1.06316483
p_int:  0.999998979
p_ni:  9.88e-7
p_wrong:  3.2e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
RAD54L2
Tdark
Family:  Enzyme
Novelty:  0.26668341
p_int:  0.999997502
p_ni:  0.000002496
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
FAM53C
Tdark
Novelty:  1.18764113
p_int:  0.999997215
p_ni:  0.000002464
p_wrong:  3.21e-7
Score:  0.808
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.99999611
p_ni:  0.000003601
p_wrong:  2.89e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
MISP
Tbio
Novelty:  0.02030151
p_int:  0.999899483
p_ni:  0.00010048
p_wrong:  3.7e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
PCBD2
Tbio
Family:  Enzyme
Novelty:  0.11676823
Score:  0.983
Data Source:  STRINGDB
HNF1A
Tbio
Family:  TF
Novelty:  0.00101291
Score:  0.766
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
4
5
98.2
eosinophil count
5
4
5
98.2
eosinophil percentage of leukocytes
2
2
2
90.3
eosinophil percentage of leukocytes
2
2
2
90.3
eosinophil percentage of granulocytes
1
1
1
83.7
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
98.2
eosinophil count
5
98.2
eosinophil percentage of leukocytes
2
90.3
eosinophil percentage of leukocytes
2
90.3
eosinophil percentage of granulocytes
1
83.7
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity tyrosine phosphorylation regulated kinase 1B
VGNC:10999
456030
Macaque
dual specificity tyrosine phosphorylation regulated kinase 1B
698848
Mouse
MGI:1330302
13549
Rat
RGD:1307223
308468
Dog
dual specificity tyrosine phosphorylation regulated kinase 1B
VGNC:40156
484506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity tyrosine phosphorylation regulated kinase 1B
Macaque
dual specificity tyrosine phosphorylation regulated kinase 1B
Mouse
Rat
Dog
dual specificity tyrosine phosphorylation regulated kinase 1B
Publication Statistics
PubMed Score 71.36
PubMed score by year
PubTator Score 48.66
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title