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Tdark
FAM32A
Protein FAM32A

Protein Summary
Description
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263384
  • ENSP00000263384
  • ENSG00000105058
  • ENST00000589852
  • ENSP00000465969

Symbol
  • OTAG12
  • OTAG12
  • OTAG-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor binding site profile
0.77
kinase perturbation
0.71
histone modification site profile
0.7
cellular component
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.995789875
p_ni:  0.004210108
p_wrong:  1.7e-8
Data Source:  BioPlex
CCDC60
Tdark
Novelty:  0.62801145
p_int:  0.957433392
p_ni:  0.030729402
p_wrong:  0.011837206
Score:  0.485
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.879698813
p_ni:  0.120301184
p_wrong:  3e-9
Data Source:  BioPlex
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
p_int:  0.855042667
p_ni:  0.144957332
p_wrong:  1e-9
Data Source:  BioPlex
CWC22
Tbio
Novelty:  0.027689
Score:  0.769
Data Source:  STRINGDB
COLGALT1
Tbio
Family:  Enzyme
Novelty:  0.14093826
Score:  0.634
Data Source:  STRINGDB
ZNF544
Tdark
Family:  TF
Novelty:  0.99233516
Score:  0.548
Data Source:  STRINGDB
RTFDC1
Tbio
Novelty:  0.06569762
Score:  0.523
Data Source:  STRINGDB
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
Score:  0.5
Data Source:  STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
Score:  0.497
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
7
9
99.5
platelet count
3
3
4
96.4
platelet crit
2
2
2
92.6
mean corpuscular hemoglobin concentration
2
2
2
91
red blood cell distribution width
2
2
2
78.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.5
platelet count
4
96.4
platelet crit
2
92.6
mean corpuscular hemoglobin concentration
2
91
red blood cell distribution width
2
78.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 32 member A
VGNC:3637
455808
Macaque
family with sequence similarity 32 member A
720909
Mouse
MGI:1915172
67922
Rat
RGD:1561287
498600
Dog
family with sequence similarity 32 member A
VGNC:40676
480644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 32 member A
Macaque
family with sequence similarity 32 member A
Mouse
Rat
Dog
family with sequence similarity 32 member A
Publication Statistics
PubMed Score 1.23
PubMed score by year
PubTator Score 0.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title