Protein Summary
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
- ENST00000263384
- ENSP00000263384
- ENSG00000105058
- ENST00000589852
- ENSP00000465969
- OTAG12
- OTAG12
- OTAG-12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
transcription factor binding site profile | 0.77 | ||
kinase perturbation | 0.71 | ||
histone modification site profile | 0.7 | ||
cellular component | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.23 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 45 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.23 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 45 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (23)
MRPL53
Novelty: 1.0076471
p_int: 0.995789875
p_ni: 0.004210108
p_wrong: 1.7e-8
Data Source: BioPlex
CCDC60
Novelty: 0.62801145
p_int: 0.957433392
p_ni: 0.030729402
p_wrong: 0.011837206
Score: 0.485
Data Source: BioPlex,STRINGDB
CCR6
Family: GPCR
Novelty: 0.00257933
p_int: 0.879698813
p_ni: 0.120301184
p_wrong: 3e-9
Data Source: BioPlex
PLG
Family: Enzyme
Novelty: 0.00004806
p_int: 0.855042667
p_ni: 0.144957332
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 5 | 7 | 9 | 99.5 | |||||
platelet count | 3 | 3 | 4 | 96.4 | |||||
platelet crit | 2 | 2 | 2 | 92.6 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 91 | |||||
red blood cell distribution width | 2 | 2 | 2 | 78.2 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 9 | 99.5 | |||||
platelet count | 4 | 96.4 | |||||
platelet crit | 2 | 92.6 | |||||
mean corpuscular hemoglobin concentration | 2 | 91 | |||||
red blood cell distribution width | 2 | 78.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 32 member A | VGNC:3637 | 455808 | |||||
Macaque | family with sequence similarity 32 member A | 720909 | ||||||
Mouse | MGI:1915172 | 67922 | ||||||
Rat | RGD:1561287 | 498600 | ||||||
Dog | family with sequence similarity 32 member A | VGNC:40676 | 480644 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 32 member A | |||||
Macaque | family with sequence similarity 32 member A | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 32 member A | |||||
Publication Statistics
PubMed Score 1.23
PubMed score by year
PubTator Score 0.83
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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