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Tbio
SAMHD1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Protein Summary
Description
Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:22056990, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:23364794, PubMed:25038827, PubMed:26101257, PubMed:22056990, PubMed:24336198, PubMed:28229507, PubMed:26294762, PubMed:26431200). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:29610582, PubMed:24217394). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262878
  • ENSP00000262878
  • ENSG00000101347
  • ENST00000646066
  • ENSP00000495432
  • ENST00000646673
  • ENSP00000493536
  • ENST00000646869
  • ENSP00000495667

Symbol
  • MOP5
  • DCIP
  • CHBL2
  • HDDC1
  • MOP-5
  • SBBI88
  • hSAMHD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.98
interacting protein
0.92
molecular function
0.91
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.55   (req: < 5)
Gene RIFs: 146   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.55   (req: >= 5)
Gene RIFs: 146   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
84.9
red blood cell distribution width
1
1
1
4.2
lymphocyte percentage of leukocytes
1
1
1
1.3
lymphocyte count
1
1
1
0.9
monocyte count
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
84.9
red blood cell distribution width
1
4.2
lymphocyte percentage of leukocytes
1
1.3
lymphocyte count
1
0.9
monocyte count
1
0.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
VGNC:10305
458223
Macaque
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
709060
Mouse
MGI:1927468
56045
Rat
RGD:1308369
311580
Dog
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
VGNC:45856
485862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Macaque
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Mouse
Rat
Dog
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Protein Structure (46 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3Z3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 46
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Metabolism
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (200)
1 – 10 of 200
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 0.999974811
p_ni: 0.000025189
Score: 0.221
Data Source: BioPlex,STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00095115
p_int: 0.999491448
p_ni: 0.000508552
Score: 0.221
Data Source: BioPlex,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.994700392
p_ni: 0.005299608
Score: 0.712
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.855157975
p_ni: 0.144842025
Score: 0.732
Data Source: BioPlex,STRINGDB
NAA10
Tbio
Family: Enzyme
Novelty: 0.00086809
p_int: 0.848323981
p_ni: 0.151676019
Score: 0.37
Data Source: BioPlex,STRINGDB
DCAF1
Tbio
Novelty: 0.0170232
Score: 0.989
Data Source: STRINGDB
BST2
Tbio
Novelty: 0.00254359
Score: 0.978
Data Source: STRINGDB
ADAR
Tbio
Family: Enzyme
Novelty: 0.00135586
Score: 0.966
Data Source: STRINGDB
MX2
Tbio
Novelty: 0.00139073
Score: 0.966
Data Source: STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  416.55

PubMed score by year
PubTator Score  217.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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