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Tbio
RWDD3
RWD domain-containing protein 3

Protein Summary
Description
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263893
  • ENSP00000263893
  • ENSG00000122481
  • ENST00000370202
  • ENSP00000359221

Symbol
  • RSUME
  • RSUME
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor binding site profile
0.83
transcription factor perturbation
0.74
kinase perturbation
0.71
cell type or tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.992
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.963
Data Source:  STRINGDB
SAE1
Tbio
Novelty:  0.01613881
Score:  0.926
Data Source:  STRINGDB
UBA2
Tbio
Novelty:  0.01582807
Score:  0.923
Data Source:  STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.676
Data Source:  STRINGDB
TMEM56
Tdark
Novelty:  0.75633366
Score:  0.598
Data Source:  STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
Score:  0.559
Data Source:  STRINGDB
SENP1
Tchem
Family:  Enzyme
Novelty:  0.00831213
Score:  0.517
Data Source:  STRINGDB
RWDD4
Tdark
Novelty:  0.36794676
Score:  0.474
Data Source:  STRINGDB
RWDD2B
Tdark
Novelty:  0.42452529
Score:  0.448
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing and activation of SUMO
Reactome
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Reactome
SUMOylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Processing and activation of SUMO
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
1
1
79.6
daytime rest measurement
1
1
1
41.9
alcohol consumption measurement
1
1
1
3
myeloid white cell count
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
79.6
daytime rest measurement
1
41.9
alcohol consumption measurement
1
3
myeloid white cell count
1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RWD domain containing 3
VGNC:1507
457042
Mouse
MGI:1920420
66568
Rat
RGD:620472
65026
Dog
RWD domain containing 3
VGNC:54066
490150
Horse
RWD domain containing 3
VGNC:50880
100057738
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RWD domain containing 3
Mouse
Rat
Dog
RWD domain containing 3
Horse
RWD domain containing 3
Publication Statistics
PubMed Score 15.33
PubMed score by year
PubTator Score 8.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title