You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPL36
60S ribosomal protein L36

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347512
  • ENSP00000252543
  • ENSG00000130255
  • ENST00000394580
  • ENSP00000378081
  • ENST00000577222
  • ENSP00000464342
  • ENST00000579649
  • ENSP00000462609

Symbol
  • L36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.84
transcription factor perturbation
0.8
hub protein
0.75
biological process
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
2
2
93.7
mean corpuscular hemoglobin concentration
1
1
1
75.2
red blood cell distribution width
2
2
2
66.6
mean corpuscular volume
1
1
1
59.6
mean reticulocyte volume
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
2
93.7
mean corpuscular hemoglobin concentration
1
75.2
red blood cell distribution width
2
66.6
mean corpuscular volume
1
59.6
mean reticulocyte volume
1
52
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L36
VGNC:2263
100611898
Macaque
60S ribosomal protein L36 pseudogene
710317
Mouse
MGI:1860603
54217
Mouse
MGI:3642480
100043215
Rat
RGD:62085
58927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L36
Macaque
60S ribosomal protein L36 pseudogene
Mouse
Mouse
Rat
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3U8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (421)
1 – 10 of 421
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.991070935
p_ni:  0.008929065
Score:  0.303
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.971636379
p_ni:  0.028363621
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.936362878
p_ni:  0.063637107
p_wrong:  1.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.935205105
p_ni:  0.064794895
Score:  0.512
Data Source:  BioPlex,STRINGDB
KNOP1
Tdark
Novelty:  0.5609503
p_int:  0.918546735
p_ni:  0.081453265
Score:  0.253
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.908372167
p_ni:  0.091627833
Score:  0.999
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.900049986
p_ni:  0.099950014
Score:  0.629
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.876013121
p_ni:  0.123986879
Data Source:  BioPlex
PES1
Tbio
Novelty:  0.07162845
p_int:  0.764875528
p_ni:  0.235124472
Score:  0.952
Data Source:  BioPlex,STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.764603894
p_ni:  0.235396106
Score:  0.337
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.03

PubMed score by year
PubTator Score  14.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: