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Tbio
NOC2L
Nucleolar complex protein 2 homolog

Protein Summary
Description
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327044
  • ENSP00000317992
  • ENSG00000188976

Symbol
  • NIR
  • NIR
  • NET7
  • NET15
  • PPP1R112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
biological process
0.92
ligand (protein) perturbation
0.83
interacting protein
0.77
drug perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
69.4
heel bone mineral density
2
1
2
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
69.4
heel bone mineral density
2
35.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOC2 like nucleolar associated transcriptional repressor
VGNC:14055
100608665
Macaque
NOC2 like nucleolar associated transcriptional repressor
697809
Mouse
MGI:1931051
57741
Rat
RGD:1309387
313777
Dog
NOC2 like nucleolar associated transcriptional repressor
VGNC:43873
489608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOC2 like nucleolar associated transcriptional repressor
Macaque
NOC2 like nucleolar associated transcriptional repressor
Mouse
Rat
Dog
NOC2 like nucleolar associated transcriptional repressor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y3T9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Phosphorylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Phosphorylation
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (354)
1 – 10 of 354
PDCD11
Tbio
Novelty: 0.02209612
p_int: 0.999855313
p_ni: 0.000144687
Score: 0.986
Data Source: BioPlex,STRINGDB
MAK16
Tdark
Novelty: 0.07717917
p_int: 0.999678911
p_ni: 0.000321061
p_wrong: 2.9e-8
Score: 0.958
Data Source: BioPlex,STRINGDB
NOC3L
Tbio
Novelty: 0.05635731
p_int: 0.999419618
p_ni: 0.000580382
Score: 0.977
Data Source: BioPlex,STRINGDB
CEBPZ
Tbio
Novelty: 0.00861664
p_int: 0.999166837
p_ni: 0.000833163
Score: 0.998
Data Source: BioPlex,STRINGDB
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.995884776
p_ni: 0.004115224
Score: 0.362
Data Source: BioPlex,STRINGDB
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.992145165
p_ni: 0.007854835
Score: 0.515
Data Source: BioPlex,STRINGDB
CCDC102A
Tdark
Novelty: 1.89784272
p_int: 0.990979719
p_ni: 0.009020278
p_wrong: 3e-9
Data Source: BioPlex
NOG
Tbio
Novelty: 0.0010373
p_int: 0.975875935
p_ni: 0.024124065
Data Source: BioPlex
DGKZ
Tbio
Family: Enzyme
Novelty: 0.01312044
p_int: 0.96716592
p_ni: 0.03283408
Data Source: BioPlex
MAGEB10
Tdark
Novelty: 2.96156972
p_int: 0.965222074
p_ni: 0.034777926
Data Source: BioPlex
Publication Statistics
PubMed Score  458.90

PubMed score by year
PubTator Score  136.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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