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Tchem
WNK2
Serine/threonine-protein kinase WNK2

Protein Summary
Description
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell sign ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297954
  • ENSP00000297954
  • ENSG00000165238

Symbol
  • KIAA1760
  • PRKWNK2
  • SDCCAG43
  • PRKWNK2
  • NY-CO-43
  • SDCCAG43
  • P/OKcl.13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
ligand (protein) perturbation
0.83
disease perturbation
0.79
PubMedID
0.65
biological process
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.63   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.63   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL248757
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
80.2
mathematical ability
1
1
1
79.4
cognitive function measurement
1
1
1
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
80.2
mathematical ability
1
79.4
cognitive function measurement
1
63.6
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
SPATA1
Tdark
p_int: 0.999998523
p_ni: 0.000001427
p_wrong: 5e-8
Data Source: BioPlex
TSC22D4
Tbio
Family: TF
Novelty: 0.25451456
p_int: 0.999998245
p_ni: 0.000001697
p_wrong: 5.8e-8
Score: 0.224
Data Source: BioPlex,STRINGDB
WNK1
Tchem
Family: Kinase
Novelty: 0.00270535
Score: 0.969
Data Source: STRINGDB
SCNN1A
Tclin
Family: IC
Novelty: 0.00900102
Score: 0.943
Data Source: STRINGDB
SCNN1G
Tclin
Family: IC
Novelty: 0.00689941
Score: 0.913
Data Source: STRINGDB
SCNN1D
Tbio
Family: IC
Novelty: 0.06191685
Score: 0.907
Data Source: STRINGDB
SCNN1B
Tclin
Family: IC
Novelty: 0.01281284
Score: 0.904
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.902
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.9
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.63

PubMed score by year
PubTator Score  24.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer