Pharos : Target Details

Tbio

Protein Summary

Description

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

Uniprot Accession IDs

Gene Name

GRIP1

Ensembl ID

ENST00000359742
ENSP00000352780
ENSG00000155974
ENST00000398016
ENSP00000381098

Symbol

GRIP
FRASRS3

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.9

hub protein	0.71

disease	0.67

microRNA	0.66

transcription factor	0.66

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.23 (req: < 5)

Gene RIFs: 15 (req: <= 3)

View Gene RIFs

Antibodies: 209 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.23 (req: >= 5)

Gene RIFs: 15 (req: > 3)

Antibodies: 209 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
basophil percentage of leukocytes	EFO_0007992	1	1	1	48.1

basophil percentage of granulocytes	EFO_0007995	1	1	1	47.3

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
basophil percentage of leukocytes	EFO_0007992	1	48.1

basophil percentage of granulocytes	EFO_0007995	1	47.3

Beta Count

Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID
Chimp	glutamate receptor interacting protein 1	VGNC:5407	452059

Macaque	glutamate receptor interacting protein 1		717885

Mouse	glutamate receptor interacting protein 1	MGI:1921303	74053

Rat	glutamate receptor interacting protein 1	RGD:621667	84016

Dog	glutamate receptor interacting protein 1	VGNC:41498	474434

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glutamate receptor interacting protein 1

Macaque	glutamate receptor interacting protein 1

Mouse	glutamate receptor interacting protein 1

Rat	glutamate receptor interacting protein 1

Dog	glutamate receptor interacting protein 1

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (127)

Reactome (6)

WikiPathways (121)

Glutamate binding, activation of AMPA receptors and synaptic plasticity (R-HSA-399721)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Glutamate binding, activation of AMPA receptors and synaptic plasticity	31 targets	R-HSA-399721

Reactome	Neuronal System	398 targets	R-HSA-112316

Reactome	Neurotransmitter receptors and postsynaptic signal transmission	186 targets	R-HSA-112314

Reactome	Trafficking of AMPA receptors	31 targets	R-HSA-399719

Reactome	Trafficking of GluR2-containing AMPA receptors	17 targets	R-HSA-416993

Name	Explore in Pharos	Explore in Source
Glutamate binding, activation of AMPA receptors and synaptic plasticity	31 targets	R-HSA-399721

Neuronal System	398 targets	R-HSA-112316

Neurotransmitter receptors and postsynaptic signal transmission	186 targets	R-HSA-112314

Trafficking of AMPA receptors	31 targets	R-HSA-399719

Trafficking of GluR2-containing AMPA receptors	17 targets	R-HSA-416993

Gene Ontology Terms (22)

Functions (6)

Components (9)

Processes (7)

Items per page:

1 – 6 of 6

GO Term	Evidence	Assigned by
glucocorticoid receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB

protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB

beta-catenin binding	Traceable Author Statement (TAS)	AgBase

androgen receptor binding	Non-traceable Author Statement (NAS)	UniProtKB

receptor signaling complex scaffold activity	Non-traceable Author Statement (NAS)	UniProtKB

transcription coactivator activity	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (128)

1 – 10 of 128

See Interactions on String-DB

FNTB

Tchem

Family: Enzyme

Novelty: 0.07434994

p_int: 1

Score: 0.228

Data Source: BioPlex,STRINGDB

PICK1

Tbio

Novelty: 0.0058265

Score: 0.994