GRIP1
Glutamate receptor-interacting protein 1
Protein Summary
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
- ENST00000359742
- ENSP00000352780
- ENSG00000155974
- ENST00000398016
- ENSP00000381098
- GRIP
- FRASRS3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.9 | ||
hub protein | 0.71 | ||
disease | 0.67 | ||
microRNA | 0.66 | ||
transcription factor | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.16 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 209 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.16 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 209 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (128)
Nearest Tclin Targets
Pathways (127)
Reactome (6)
WikiPathways (121)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glutamate binding, activation of AMPA receptors and synaptic plasticity | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Reactome | Trafficking of AMPA receptors | ||||
Reactome | Trafficking of GluR2-containing AMPA receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glutamate binding, activation of AMPA receptors and synaptic plasticity | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Trafficking of AMPA receptors | ||||
Trafficking of GluR2-containing AMPA receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (6)
Components (9)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | AgBase | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
basophil count | 5 | 4 | 5 | 87.8 | |||||
basophil percentage of leukocytes | 2 | 2 | 2 | 81 | |||||
age at menopause | 1 | 1 | 1 | 80.4 | |||||
basophil percentage of granulocytes | 1 | 1 | 1 | 68.3 | |||||
1 | 1 | 1 | 42 | ||||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
basophil count | 5 | 87.8 | |||||
basophil percentage of leukocytes | 2 | 81 | |||||
age at menopause | 1 | 80.4 | |||||
basophil percentage of granulocytes | 1 | 68.3 | |||||
1 | 42 | ||||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutamate receptor interacting protein 1 | VGNC:5407 | 452059 | |||||
Macaque | glutamate receptor interacting protein 1 | 717885 | ||||||
Mouse | MGI:1921303 | 74053 | ||||||
Rat | RGD:621667 | 84016 | ||||||
Dog | glutamate receptor interacting protein 1 | VGNC:41498 | 474434 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutamate receptor interacting protein 1 | |||||
Macaque | glutamate receptor interacting protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamate receptor interacting protein 1 | |||||
Publication Statistics
PubMed Score 281.16
PubMed score by year
PubTator Score 377.10
PubTator score by year
Related Publications
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Text |
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