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Tbio
TSC22D4
TSC22 domain family protein 4

Protein Summary
Description
Transcriptional repressor. TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300181
  • ENSP00000300181
  • ENSG00000166925
  • ENST00000393991
  • ENSP00000377560

Symbol
  • THG1
  • TILZ2
  • THG1
  • THG-1
  • TILZ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
transcription factor
0.74
drug perturbation
0.71
tissue sample
0.61
small molecule perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
1
4
87.3
hematocrit
1
2
2
85.7
hemoglobin measurement
1
1
1
81.5
3
2
0
6.7
76.2
family history of Alzheimer’s disease
2
2
0
7.5
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
87.3
hematocrit
2
85.7
hemoglobin measurement
1
81.5
0
6.7
76.2
family history of Alzheimer’s disease
0
7.5
76.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TSC22 domain family member 4
VGNC:14106
463600
Mouse
MGI:1926079
78829
Rat
RGD:1584380
684980
Dog
TSC22 domain family member 4
VGNC:47894
479734
Horse
TSC22 domain family member 4
VGNC:24574
100068974
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TSC22 domain family member 4
Mouse
Rat
Dog
TSC22 domain family member 4
Horse
TSC22 domain family member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y3Q8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (52)
1 – 10 of 52
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
p_int:  0.999999998
p_ni:  2e-9
Score:  0.831
Data Source:  BioPlex,STRINGDB
TSC22D1
Tbio
Family:  TF
Novelty:  0.01934962
p_int:  0.999999997
p_ni:  3e-9
Score:  0.807
Data Source:  BioPlex,STRINGDB
TSC22D2
Tdark
Family:  TF
Novelty:  0.30718123
p_int:  0.999999083
p_ni:  9e-9
p_wrong:  9.08e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.999998982
p_ni:  0.000001018
Score:  0.825
Data Source:  BioPlex,STRINGDB
TTL
Tchem
Family:  Enzyme
Novelty:  0.03494724
p_int:  0.999998702
p_ni:  0.000001294
p_wrong:  4e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
WNK2
Tchem
Family:  Kinase
Novelty:  0.05450998
p_int:  0.999998245
p_ni:  0.000001697
p_wrong:  5.8e-8
Score:  0.224
Data Source:  BioPlex,STRINGDB
WNK3
Tchem
Family:  Kinase
Novelty:  0.03382701
p_int:  0.999993944
p_ni:  0.000006056
Score:  0.224
Data Source:  BioPlex,STRINGDB
MAD2L1BP
Tbio
Novelty:  0.48374717
p_int:  0.999992397
p_ni:  0.00000474
p_wrong:  0.000002863
Score:  0.181
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.999991838
p_ni:  0.000008162
Data Source:  BioPlex
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999952122
p_ni:  0.000047878
Data Source:  BioPlex
Publication Statistics
PubMed Score  5.45

PubMed score by year
PubTator Score  5.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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