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Tclin
HCN4
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Protein Summary
Description
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261917
  • ENSP00000261917
  • ENSG00000138622

Symbol
  • SSS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
biological process
0.68
microRNA
0.66
cell type or tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.72   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.72   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
96.9
waist-hip ratio
1
1
1
64
heart rate variability measurement
2
1
3
60.3
heart rate
1
1
1
30.4
electrocardiography
1
1
9
23.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
96.9
waist-hip ratio
1
64
heart rate variability measurement
3
60.3
heart rate
1
30.4
electrocardiography
9
23.6
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
HCN channels (R-HSA-1296061)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HCN channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
HCN channels
Neuronal System
Potassium Channels
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (123)
1 – 10 of 123
HCN2
Tclin
Family: IC
Novelty: 0.02421034
Score: 0.951
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.853
Data Source: STRINGDB
KCNK5
Tchem
Family: IC
Novelty: 0.00932619
Score: 0.831
Data Source: STRINGDB
HCN1
Tclin
Family: IC
Novelty: 0.02529554
Score: 0.831
Data Source: STRINGDB
SCN5A
Tclin
Family: IC
Novelty: 0.00050944
Score: 0.814
Data Source: STRINGDB
MRPL49
Tbio
Novelty: 0.03727552
Score: 0.8
Data Source: STRINGDB
CAV3
Tbio
Novelty: 0.00190092
Score: 0.798
Data Source: STRINGDB
GJA5
Tbio
Novelty: 0.00195794
Score: 0.792
Data Source: STRINGDB
RANGRF
Tbio
Family: Enzyme
Novelty: 0.02750539
Score: 0.778
Data Source: STRINGDB
PEX5L
Tbio
Novelty: 0.01922466
Score: 0.776
Data Source: STRINGDB
Publication Statistics
PubMed Score  481.72

PubMed score by year
PubTator Score  178.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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