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Tbio
TMED3
Transmembrane emp24 domain-containing protein 3

Protein Summary
Description
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299705
  • ENSP00000299705
  • ENSG00000166557
  • ENST00000424155
  • ENSP00000414983

Symbol
  • C15orf22
  • p26
  • P24B
  • p24g4
  • C15orf22
  • p24gamma4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.71
cellular component
0.66
kinase perturbation
0.66
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
BLZF1
Tbio
Novelty:  0.04344183
p_int:  0.999885947
p_ni:  0.000114053
Score:  0.709
Data Source:  BioPlex,STRINGDB
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.999600247
p_ni:  0.000399753
Score:  0.99
Data Source:  BioPlex,STRINGDB
TMED4
Tdark
Novelty:  0.22372593
p_int:  0.993416735
p_ni:  0.006583265
Score:  0.888
Data Source:  BioPlex,STRINGDB
HS1BP3
Tbio
Novelty:  0.08876712
p_int:  0.992035116
p_ni:  0.007964883
p_wrong:  1e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
CCPG1
Tbio
Novelty:  0.07685013
p_int:  0.979151262
p_ni:  0.020848738
Data Source:  BioPlex
TMED10
Tbio
Novelty:  0.02742083
p_int:  0.965514524
p_ni:  0.034485476
Score:  0.993
Data Source:  BioPlex,STRINGDB
LNPK
Tbio
Novelty:  0.07736762
p_int:  0.848973567
p_ni:  0.145231414
p_wrong:  0.005795019
Score:  0.226
Data Source:  BioPlex,STRINGDB
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.832069658
p_ni:  0.167930342
Score:  0.16
Data Source:  BioPlex,STRINGDB
GORASP1
Tbio
Novelty:  0.02332405
Score:  0.962
Data Source:  STRINGDB
TMED9
Tbio
Novelty:  0.24024246
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 3
VGNC:1586
740721
Macaque
transmembrane p24 trafficking protein 3
711993
Mouse
MGI:1913361
66111
Rat
RGD:1303327
300888
Dog
transmembrane p24 trafficking protein 3
VGNC:47438
100685718
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 3
Macaque
transmembrane p24 trafficking protein 3
Mouse
Rat
Dog
transmembrane p24 trafficking protein 3
Publication Statistics
PubMed Score 17.19
PubMed score by year
PubTator Score 88.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title