Tbio TMED3 Transmembrane emp24 domain-containing protein 3

Protein Summary

Description

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network.

Uniprot Accession IDs

• Q9Y3Q3
• A8K069
• B4DN05
• Q2T9F8

Gene Name

• TMED3

Ensembl ID

• ENST00000299705
• ENSP00000299705
• ENSG00000166557
• ENST00000424155
• ENSP00000414983

Symbol

• C15orf22
• p26
• P24B
• p24g4
• C15orf22
• p24gamma4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
histone modification site profile	0.71
cellular component	0.66
kinase perturbation	0.66
tissue sample	0.59

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Transmembrane Emp24 Domain-containing Protein 3

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Transmembrane Emp24 Domain-containing Protein 3

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Transmembrane Emp24 Domain-containing Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.87   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.87   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0