Tchem NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2

Protein Summary

Description

Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate. This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9Y3Q0
• B3KQR4
• Q4KKV4
• Q4VAM9

Gene Name

• NAALAD2

Ensembl ID

• ENST00000375944
• ENSP00000365111
• ENSG00000077616
• ENST00000534061
• ENSP00000432481
• ENST00000644696
• ENSP00000494081
• ENSG00000285516
• ENST00000647397
• ENSP00000494766

Symbol

• GCPIII
• GPCIII
• NAADALASE2
• NAALADASE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.7
cell line	0.66
gene perturbation	0.66
histone modification site profile	0.63
PubMedID	0.6

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / N-acetylated-alpha-linked Acidic Dipeptidase 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / N-acetylated-alpha-linked Acidic Dipeptidase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0