Tbio STARD13 StAR-related lipid transfer protein 13

Protein Summary

Description

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9Y3M8
• A2A309
• A2A310
• Q5HYH1
• Q5TAE3
• Q6UN61
• Q86TP6
• Q86WQ3
• Q86XT1

Gene Name

• STARD13

Ensembl ID

• ENST00000255486
• ENSP00000255486
• ENSG00000133121
• ENST00000336934
• ENSP00000338785
• ENST00000399365
• ENSP00000382300

Symbol

• DLC2
• GT650
• DLC2
• GT650
• ARHGAP37
• LINC00464

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
transcription factor	0.78
PubMedID	0.74
kinase perturbation	0.66
microRNA	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.77   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.77   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0