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Tbio
CBY1
Protein chibby homolog 1

Protein Summary
Description
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216029
  • ENSP00000216029
  • ENSG00000100211
  • ENST00000396811
  • ENSP00000380026

Symbol
  • ARB1
  • C22orf2
  • CBY
  • PGEA1
  • CBY
  • arb1
  • PGEA1
  • C22orf2
  • Chibby1
  • PIGEA14
  • PIGEA-14
  • HS508I15A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
cell type or tissue
0.8
cellular component
0.65
tissue sample
0.57
transcription factor binding site profile
0.56


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.9   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.9   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chibby family member 1, beta catenin antagonist
VGNC:5237
100610754
Mouse
MGI:1920989
73739
Rat
RGD:708481
246768
Dog
chibby family member 1, beta catenin antagonist
VGNC:38770
481252
Horse
chibby family member 1, beta catenin antagonist
VGNC:16101
100070115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chibby family member 1, beta catenin antagonist
Mouse
Rat
Dog
chibby family member 1, beta catenin antagonist
Horse
chibby family member 1, beta catenin antagonist
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3M2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Protein-Protein Interactions (81)
1 – 10 of 81
ZNF777
Tdark
Family: TF
Novelty: 1.20195224
p_int: 0.999938864
p_ni: 0.000042465
p_wrong: 0.000018671
Data Source: BioPlex
FKBP9
Tbio
Family: Enzyme
Novelty: 0.16472204
p_int: 0.999928854
p_ni: 0.00004747
p_wrong: 0.000023676
Score: 0.243
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.999906185
p_ni: 0.000093729
p_wrong: 8.6e-8
Data Source: BioPlex
PAGE1
Tbio
Novelty: 0.02731969
p_int: 0.997249044
p_ni: 0.001365883
p_wrong: 0.001385073
Data Source: BioPlex
OLFM2
Tbio
Novelty: 0.06929963
p_int: 0.965778396
p_ni: 0.000017451
p_wrong: 0.034204153
Score: 0.167
Data Source: BioPlex,STRINGDB
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.936131035
p_ni: 0.000047606
p_wrong: 0.06382136
Score: 0.179
Data Source: BioPlex,STRINGDB
FAM206A
Tbio
Novelty: 0.01675868
p_int: 0.882735174
p_ni: 0.000041175
p_wrong: 0.117223652
Score: 0.309
Data Source: BioPlex,STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
Score: 0.997
Data Source: Reactome,STRINGDB
SFN
Tbio
Novelty: 0.00340233
Score: 0.988
Data Source: STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.90

PubMed score by year
PubTator Score  13.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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