You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SH3BP1
SH3 domain-binding protein 1

Protein Summary
Description
GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357436
  • ENSP00000350018
  • ENSG00000100092
  • ENST00000417536
  • ENSP00000411979
  • ENST00000649765
  • ENSP00000497104

Symbol
  • ARHGAP43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.89
disease perturbation
0.74
cell type or tissue
0.7
transcription factor
0.64
transcription factor binding site profile
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.08   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.999999995
p_ni:  1e-9
p_wrong:  4e-9
Score:  0.821
Data Source:  BioPlex,STRINGDB
ARHGAP17
Tbio
Family:  Enzyme
Novelty:  0.06611987
p_int:  0.999999966
p_ni:  3.2e-8
p_wrong:  1e-9
Score:  0.848
Data Source:  BioPlex,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999999377
p_ni:  5.87e-7
p_wrong:  3.6e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
ARHGAP44
Tbio
Family:  Enzyme
Novelty:  0.11113234
p_int:  0.99999845
p_ni:  0.00000155
Score:  0.873
Data Source:  BioPlex,STRINGDB
EXOC8
Tbio
Novelty:  0.03090842
p_int:  0.999998274
p_ni:  0.00000149
p_wrong:  2.36e-7
Score:  0.393
Data Source:  BioPlex,STRINGDB
THRSP
Tbio
Novelty:  0.00938864
p_int:  0.999995021
p_ni:  0.000004979
Data Source:  BioPlex
G3BP1
Tbio
Family:  Enzyme
Novelty:  0.00589987
Score:  0.633
Data Source:  STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
Score:  0.61
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.56
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.559
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
2
58.9
age-related hearing impairment
2
1
1
1.1
52.7
serum albumin measurement
1
1
1
50.6
pulse pressure measurement
1
1
1
46.9
cognitive function measurement
3
1
3
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
58.9
age-related hearing impairment
1
1.1
52.7
serum albumin measurement
1
50.6
pulse pressure measurement
1
46.9
cognitive function measurement
3
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain binding protein 1
VGNC:7343
458815
Macaque
SH3 domain binding protein 1
700647
Mouse
MGI:104603
20401
Rat
RGD:1306275
300067
Dog
SH3 domain binding protein 1
VGNC:46117
481265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain binding protein 1
Macaque
SH3 domain binding protein 1
Mouse
Rat
Dog
SH3 domain binding protein 1
Publication Statistics
PubMed Score 0.08
PubMed score by year
PubTator Score 7.56
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title