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Tbio
FBXO7
F-box only protein 7

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266087
  • ENSP00000266087
  • ENSG00000100225
  • ENST00000397426
  • ENSP00000380571
  • ENST00000452138
  • ENSP00000388547

Symbol
  • FBX7
  • FBX
  • FBX7
  • PKPS
  • FBX07
  • PARK15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
virus perturbation
0.99
biological process
0.9
cell type or tissue
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.63   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.63   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
93.3
red blood cell distribution width
4
3
4
91.6
mean corpuscular volume
3
4
4
90.7
red blood cell density measurement
1
1
1
83.1
erythrocyte measurement
1
1
1
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
93.3
red blood cell distribution width
4
91.6
mean corpuscular volume
4
90.7
red blood cell density measurement
1
83.1
erythrocyte measurement
1
65.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 7
VGNC:5980
470266
Macaque
F-box protein 7
717317
Mouse
MGI:1917004
69754
Rat
RGD:1305648
366854
Dog
F-box protein 7
VGNC:40789
474522
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 7
Macaque
F-box protein 7
Mouse
Rat
Dog
F-box protein 7
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3I1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (408)
1 – 10 of 408
PSMF1
Tbio
Novelty: 0.0364376
p_int: 0.999998883
p_ni: 0.00000111
p_wrong: 7e-9
Score: 0.889
Data Source: BioPlex,STRINGDB
PSMG2
Tbio
Novelty: 0.11082503
p_int: 0.99986863
p_ni: 0.00013137
Score: 0.775
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.06547657
p_int: 0.999806468
p_ni: 0.000193532
Score: 0.584
Data Source: BioPlex,STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
p_int: 0.999621296
p_ni: 0.000378704
Score: 0.787
Data Source: BioPlex,STRINGDB
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.999591552
p_ni: 0.000408365
p_wrong: 8.3e-8
Score: 0.666
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
p_int: 0.998876399
p_ni: 0.001123601
Score: 0.974
Data Source: BioPlex,STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
p_int: 0.998823899
p_ni: 0.001176101
Score: 0.787
Data Source: BioPlex,STRINGDB
PSMA5
Tbio
Family: Enzyme
Novelty: 0.03862668
p_int: 0.998389918
p_ni: 0.00160912
p_wrong: 9.62e-7
Data Source: BioPlex
YAF2
Tbio
Novelty: 0.10772286
p_int: 0.99805542
p_ni: 0.001944296
p_wrong: 2.84e-7
Data Source: BioPlex
FBXW2
Tbio
Novelty: 0.01492058
p_int: 0.996836236
p_ni: 0.000534718
p_wrong: 0.002629046
Score: 0.932
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  98.63

PubMed score by year
PubTator Score  46.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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