Tbio RTCB tRNA-splicing ligase RtcB homolog

Protein Summary

Description

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.

Uniprot Accession IDs

• Q9Y3I0
• B2R6A8
• Q6IAI0
• Q9BWL4
• Q9NTH1
• Q9P037
• Q9P0J3

Gene Name

• RTCB

Ensembl ID

• ENST00000216038
• ENSP00000216038
• ENSG00000100220

Symbol

• C22orf28
• FAAP
• HSPC117
• C22orf28
• DJ149A16.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.96
molecular function	0.96
transcription factor perturbation	0.8
tissue sample	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.93   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.93   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0