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Tbio
RTCB
tRNA-splicing ligase RtcB homolog

Protein Summary
Description
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216038
  • ENSP00000216038
  • ENSG00000100220

Symbol
  • C22orf28
  • FAAP
  • HSPC117
  • C22orf28
  • DJ149A16.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.96
molecular function
0.96
transcription factor perturbation
0.8
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.66   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.66   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (73)
1 – 10 of 73
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
p_int:  0.955949187
p_ni:  0.044050813
Score:  0.998
Data Source:  BioPlex,STRINGDB
RTRAF
Tbio
Novelty:  0.03996206
Score:  0.999
Data Source:  STRINGDB
FAM98B
Tdark
Novelty:  0.47641513
Score:  0.998
Data Source:  STRINGDB
C2orf49
Tbio
Novelty:  0.03911934
Score:  0.996
Data Source:  STRINGDB
ZBTB8OS
Tbio
Family:  Enzyme
Novelty:  0.03929334
Score:  0.991
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
PPP1R8
Tbio
Family:  Enzyme
Novelty:  0.00138054
Score:  0.832
Data Source:  STRINGDB
MTMR12
Tbio
Novelty:  0.11861954
Score:  0.802
Data Source:  STRINGDB
FAM98A
Tdark
Novelty:  0.30067413
Score:  0.801
Data Source:  STRINGDB
RTCA
Tbio
Family:  Enzyme
Novelty:  0.03086235
Score:  0.798
Data Source:  STRINGDB
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
4
4
96.5
mean corpuscular hemoglobin concentration
2
2
2
95.6
red blood cell distribution width
4
3
4
94.6
mean reticulocyte volume
1
2
2
87.3
red blood cell density measurement
1
1
1
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
96.5
mean corpuscular hemoglobin concentration
2
95.6
red blood cell distribution width
4
94.6
mean reticulocyte volume
2
87.3
red blood cell density measurement
1
84.7
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA 2',3'-cyclic phosphate and 5'-OH ligase
VGNC:10112
458782
Macaque
RNA 2',3'-cyclic phosphate and 5'-OH ligase
717258
Mouse
MGI:106379
28088
Rat
RGD:1303261
362855
Dog
RNA 2',3'-cyclic phosphate and 5'-OH ligase
VGNC:49844
474524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA 2',3'-cyclic phosphate and 5'-OH ligase
Macaque
RNA 2',3'-cyclic phosphate and 5'-OH ligase
Mouse
Rat
Dog
RNA 2',3'-cyclic phosphate and 5'-OH ligase
Publication Statistics
PubMed Score 86.66
PubMed score by year
PubTator Score 43.85
PubTator score by year