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Tbio
PTRH2
Peptidyl-tRNA hydrolase 2, mitochondrial

Protein Summary
Description
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393038
  • ENSP00000376758
  • ENSG00000141378
  • ENST00000470557
  • ENSP00000464327

Symbol
  • BIT1
  • PTH2
  • PTH
  • BIT1
  • PTH2
  • PTH 2
  • CFAP37
  • IMNEPD
  • CGI-147
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.84
interacting protein
0.83
transcription factor binding site profile
0.82
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.18   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.18   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999663047
p_ni:  0.000336938
p_wrong:  1.4e-8
Data Source:  BioPlex
TLR5
Tbio
Novelty:  0.00110868
p_int:  0.999235339
p_ni:  0.000764661
Data Source:  BioPlex
MINDY2
Tbio
Novelty:  0.46783751
p_int:  0.989215673
p_ni:  0.010784316
p_wrong:  1e-8
Score:  0.155
Data Source:  BioPlex,STRINGDB
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.976942568
p_ni:  0.023057431
p_wrong:  1e-9
Data Source:  BioPlex
CD7
Tbio
Novelty:  0.00107937
p_int:  0.975174131
p_ni:  0.024825813
p_wrong:  5.6e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.942306186
p_ni:  0.057693813
p_wrong:  1e-9
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.934644693
p_ni:  0.065355258
p_wrong:  4.9e-8
Data Source:  BioPlex
CLEC5A
Tbio
Novelty:  0.01710591
p_int:  0.899936853
p_ni:  0.100063081
p_wrong:  6.6e-8
Data Source:  BioPlex
TNFRSF10B
Tbio
Novelty:  0.00054433
p_int:  0.89735811
p_ni:  0.102641889
Data Source:  BioPlex
SIGLEC10
Tbio
Novelty:  0.02858542
p_int:  0.884587146
p_ni:  0.115325508
p_wrong:  0.000087345
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (64)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
94.6
leukocyte count
2
2
2
93.8
neutrophil count
3
2
3
93.1
4
3
0
1.1
92.9
hemoglobin measurement
2
2
2
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
94.6
leukocyte count
2
93.8
neutrophil count
3
93.1
0
1.1
92.9
hemoglobin measurement
2
88.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidyl-tRNA hydrolase 2
VGNC:9546
101059491
Macaque
peptidyl-tRNA hydrolase 2
711736
Mouse
MGI:2444848
217057
Rat
RGD:1306819
287593
Dog
peptidyl-tRNA hydrolase 2
VGNC:45202
100682594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidyl-tRNA hydrolase 2
Macaque
peptidyl-tRNA hydrolase 2
Mouse
Rat
Dog
peptidyl-tRNA hydrolase 2
Publication Statistics
PubMed Score 51.18
PubMed score by year
PubTator Score 18.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title