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Tbio
BOLA1
BolA-like protein 1

Protein Summary
Description
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369150
  • ENSP00000358146
  • ENSG00000178096
  • ENST00000369152
  • ENSP00000358148
  • ENST00000369153
  • ENSP00000358149

Symbol
  • CGI-143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.84
transcription factor perturbation
0.74
tissue sample
0.61
transcription factor binding site profile
0.61


Related Tools
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ARCHS4
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
bolA family member 1
705297
Mouse
MGI:1916418
69168
Rat
RGD:1310586
365875
Cow
bolA family member 1
VGNC:50092
509530
Pig
bolA family member 1
100152975
Species
Name
OMA
EggNOG
Inparanoid
Macaque
bolA family member 1
Mouse
Rat
Cow
bolA family member 1
Pig
bolA family member 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3E2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (58)
1 – 10 of 58
GLRX3
Tbio
Novelty: 0.0096265
p_int: 0.999995025
p_ni: 0.000004975
Score: 0.98
Data Source: BioPlex,STRINGDB
PLSCR1
Tbio
Family: Enzyme
Novelty: 0.01483138
p_int: 0.999767419
p_ni: 0.000228383
p_wrong: 0.000004198
Score: 0.188
Data Source: BioPlex,STRINGDB
CIAPIN1
Tbio
Novelty: 0.01359005
p_int: 0.997856869
p_ni: 0.002143131
Score: 0.962
Data Source: BioPlex,STRINGDB
RGS20
Tbio
Novelty: 0.04087618
p_int: 0.996770251
p_ni: 0.003229644
p_wrong: 1.06e-7
Score: 0.445
Data Source: BioPlex,STRINGDB
COMMD8
Tdark
Novelty: 0.33240242
p_int: 0.993079276
p_ni: 0.006920721
p_wrong: 3e-9
Data Source: BioPlex
TINAG
Tbio
Novelty: 0.04582927
p_int: 0.990102639
p_ni: 0.000744952
p_wrong: 0.009152409
Data Source: BioPlex
UROS
Tbio
Family: Enzyme
Novelty: 0.00938683
p_int: 0.987976117
p_ni: 0.012003665
p_wrong: 0.000020217
Score: 0.226
Data Source: BioPlex,STRINGDB
RAB17
Tbio
Family: Enzyme
Novelty: 0.04352198
p_int: 0.963551898
p_ni: 0.03346628
p_wrong: 0.002981823
Score: 0.255
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.950005311
p_ni: 0.049991744
p_wrong: 0.000002946
Data Source: BioPlex
PTP4A1
Tchem
Family: Enzyme
Novelty: 0.02863007
p_int: 0.910087467
p_ni: 0.011762816
p_wrong: 0.078149716
Data Source: BioPlex
Publication Statistics
PubMed Score  11.46

PubMed score by year
PubTator Score  2.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer