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Tbio
BOLA1
BolA-like protein 1

Protein Summary
Description
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369150
  • ENSP00000358146
  • ENSG00000178096
  • ENST00000369152
  • ENSP00000358148
  • ENST00000369153
  • ENSP00000358149

Symbol
  • CGI-143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.84
transcription factor perturbation
0.74
tissue sample
0.61
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
GLRX3
Tbio
Novelty:  0.0096265
p_int:  0.999995025
p_ni:  0.000004975
Score:  0.98
Data Source:  BioPlex,STRINGDB
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
p_int:  0.999767419
p_ni:  0.000228383
p_wrong:  0.000004198
Score:  0.188
Data Source:  BioPlex,STRINGDB
CIAPIN1
Tbio
Novelty:  0.01359005
p_int:  0.997856869
p_ni:  0.002143131
Score:  0.962
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.996770251
p_ni:  0.003229644
p_wrong:  1.06e-7
Score:  0.445
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.993079276
p_ni:  0.006920721
p_wrong:  3e-9
Data Source:  BioPlex
TINAG
Tbio
Novelty:  0.04582927
p_int:  0.990102639
p_ni:  0.000744952
p_wrong:  0.009152409
Data Source:  BioPlex
UROS
Tbio
Family:  Enzyme
Novelty:  0.00938683
p_int:  0.987976117
p_ni:  0.012003665
p_wrong:  0.000020217
Score:  0.226
Data Source:  BioPlex,STRINGDB
RAB17
Tbio
Family:  Enzyme
Novelty:  0.04352198
p_int:  0.963551898
p_ni:  0.03346628
p_wrong:  0.002981823
Score:  0.255
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.950005311
p_ni:  0.049991744
p_wrong:  0.000002946
Data Source:  BioPlex
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.910087467
p_ni:  0.011762816
p_wrong:  0.078149716
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
10
97.7
body height
6
3
5
5.1
92.7
BMI-adjusted waist circumference
7
3
15
88.8
sex hormone-binding globulin measurement
5
3
5
87.9
body fat distribution
2
1
6
87.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
97.7
body height
5
5.1
92.7
BMI-adjusted waist circumference
15
88.8
sex hormone-binding globulin measurement
5
87.9
body fat distribution
6
87.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
bolA family member 1
705297
Mouse
MGI:1916418
69168
Rat
RGD:1310586
365875
Cow
bolA family member 1
VGNC:50092
509530
Pig
bolA family member 1
100152975
Species
Name
OMA
EggNOG
Inparanoid
Macaque
bolA family member 1
Mouse
Rat
Cow
bolA family member 1
Pig
bolA family member 1
Publication Statistics
PubMed Score 11.46
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
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PMID
Year
Title