Tbio BOLA1 BolA-like protein 1

Protein Summary

Description

Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).

Uniprot Accession IDs

• Q9Y3E2
• B2R7K2
• D3DUZ4
• Q5QNY0

Gene Name

• BOLA1

Ensembl ID

• ENST00000369150
• ENSP00000358146
• ENSG00000178096
• ENST00000369152
• ENSP00000358148
• ENST00000369153
• ENSP00000358149

Symbol

• CGI-143

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
histone modification site profile	0.84
transcription factor perturbation	0.74
tissue sample	0.61
transcription factor binding site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.92   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.92   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0