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Tbio
AK6
Adenylate kinase isoenzyme 6

Protein Summary
Description
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380818
  • ENSP00000370197
  • ENSG00000085231
  • ENST00000380822
  • ENSP00000370201
  • ENST00000612207
  • ENSP00000484679
  • ENSG00000279247
  • ENST00000620269
  • ENSP00000480829

Symbol
  • CINAP
  • CIP
  • CINAP
  • AD-004
  • hCINAP
  • CGI-137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease
0.75
tissue
0.61
cellular component
0.58
biological term
0.33


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
94.3
neutrophil count
3
3
3
94.3
myeloid white cell count
2
2
2
90.1
myeloid white cell count
2
2
2
90.1
leukocyte count
2
2
2
86.1
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
94.3
neutrophil count
3
94.3
myeloid white cell count
2
90.1
myeloid white cell count
2
90.1
leukocyte count
2
86.1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3D8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (206)
1 – 10 of 206
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999998949
p_ni:  0.000001051
Score:  0.981
Data Source:  BioPlex,STRINGDB
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999998282
p_ni:  0.000001717
Score:  0.782
Data Source:  BioPlex,STRINGDB
TFEB
Tbio
Family:  TF
Novelty:  0.00248413
p_int:  0.999939829
p_ni:  0.000060171
Score:  0.189
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999898139
p_ni:  0.00010186
Score:  0.909
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.999833308
p_ni:  0.000166692
Score:  0.979
Data Source:  BioPlex,STRINGDB
TAF6L
Tdark
Family:  Enzyme
Novelty:  0.7411477
p_int:  0.999803749
p_ni:  0.000196251
Score:  0.972
Data Source:  BioPlex,STRINGDB
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.999598968
p_ni:  0.000401032
Score:  0.972
Data Source:  BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.99624812
p_ni:  0.003751878
p_wrong:  2e-9
Score:  0.966
Data Source:  BioPlex,STRINGDB
TRPC5
Tchem
Family:  IC
Novelty:  0.00406517
p_int:  0.965686066
p_ni:  0.034313934
Score:  0.282
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.803110684
p_ni:  0.196872706
p_wrong:  0.00001661
Data Source:  BioPlex
Publication Statistics
PubMed Score  11.51

PubMed score by year
PubTator Score  27.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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