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Tbio
AK6
Adenylate kinase isoenzyme 6

Protein Summary
Description
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380818
  • ENSP00000370197
  • ENSG00000085231
  • ENST00000380822
  • ENSP00000370201
  • ENST00000612207
  • ENSP00000484679
  • ENSG00000279247
  • ENST00000620269
  • ENSP00000480829

Symbol
  • CINAP
  • CIP
  • CINAP
  • AD-004
  • hCINAP
  • CGI-137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease
0.75
tissue
0.61
cellular component
0.58
biological term
0.33


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.37   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.37   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Protein-Protein Interactions (206)
1 – 10 of 206
TAF8
Tbio
Novelty: 0.00733106
p_int: 0.999998949
p_ni: 0.000001051
Score: 0.981
Data Source: BioPlex,STRINGDB
TAF7L
Tbio
Novelty: 0.04474511
p_int: 0.999998282
p_ni: 0.000001717
Score: 0.782
Data Source: BioPlex,STRINGDB
TFEB
Tbio
Family: TF
Novelty: 0.00333365
p_int: 0.999939829
p_ni: 0.000060171
Score: 0.189
Data Source: BioPlex,STRINGDB
TADA2B
Tbio
Family: TF
Novelty: 0.09308511
p_int: 0.999898139
p_ni: 0.00010186
Score: 0.909
Data Source: BioPlex,STRINGDB
RPS14
Tbio
Novelty: 0.0062093
p_int: 0.999833308
p_ni: 0.000166692
Score: 0.979
Data Source: BioPlex,STRINGDB
TAF6L
Tdark
Family: Enzyme
Novelty: 1.89781022
p_int: 0.999803749
p_ni: 0.000196251
Score: 0.972
Data Source: BioPlex,STRINGDB
TADA1
Tdark
Novelty: 0.16748286
p_int: 0.999598968
p_ni: 0.000401032
Score: 0.972
Data Source: BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty: 0.33771107
p_int: 0.99624812
p_ni: 0.003751878
p_wrong: 2e-9
Score: 0.966
Data Source: BioPlex,STRINGDB
TRPC5
Tchem
Family: IC
Novelty: 0.00493878
p_int: 0.965686066
p_ni: 0.034313934
Score: 0.282
Data Source: BioPlex,STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.00183456
p_int: 0.803110684
p_ni: 0.196872706
p_wrong: 0.00001661
Data Source: BioPlex
Publication Statistics
PubMed Score  6.37

PubMed score by year
PubTator Score  27.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer