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Tbio
PAM16
Mitochondrial import inner membrane translocase subunit TIM16

Protein Classes
Protein Summary
Description
Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be important in reactive oxygen species (ROS) homeostasis. Mutations in this gene cause Megarbane-Dagher-Melike type spondylometaphyseal dysplasia, an early lethal skeletal dysplasia characterized by short stature, developmental delay and other skeletal abnormalities. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318059
  • ENSP00000315693
  • ENSG00000217930
  • ENST00000576217
  • ENSP00000461047
  • ENST00000616009
  • ENSP00000484240
  • ENSG00000282228
  • ENST00000634045
  • ENSP00000487678

Symbol
  • MAGMAS
  • TIM16
  • TIMM16
  • TIM16
  • MAGMAS
  • SMDMDM
  • TIMM16
  • CGI-136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
cellular component
0.69
histone modification site profile
0.65
virus perturbation
0.64
transcription factor
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (50)
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
16
26
95.7
BMI-adjusted waist-hip ratio
10
16
26
95.7
BMI-adjusted hip circumference
3
12
13
92.6
BMI-adjusted hip circumference
3
12
13
92.6
hip circumference
1
5
5
87.5
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
26
95.7
BMI-adjusted waist-hip ratio
26
95.7
BMI-adjusted hip circumference
13
92.6
BMI-adjusted hip circumference
13
92.6
hip circumference
5
87.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913699
66449
Rat
RGD:1598163
679907
Dog
presequence translocase associated motor 16
VGNC:54054
444856
Horse
presequence translocase associated motor 16
102147487
Cow
presequence translocase associated motor 16
444880
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
presequence translocase associated motor 16
Horse
presequence translocase associated motor 16
Cow
presequence translocase associated motor 16
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y3D7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Genetic Interaction (IGI)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (91)
1 – 10 of 91
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.975007405
p_ni:  0.02490987
p_wrong:  0.000082725
Score:  0.167
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.953350514
p_ni:  0.010026157
p_wrong:  0.036623329
Data Source:  BioPlex
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.8937339
p_ni:  0.106110384
p_wrong:  0.000155717
Score:  0.177
Data Source:  BioPlex,STRINGDB
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
p_int:  0.815974406
p_ni:  0.183919184
p_wrong:  0.00010641
Score:  0.188
Data Source:  BioPlex,STRINGDB
DNAJC19
Tbio
Family:  Enzyme
Novelty:  0.02938164
Score:  0.999
Data Source:  STRINGDB
TIMM44
Tbio
Family:  Enzyme
Novelty:  0.020862
Score:  0.997
Data Source:  STRINGDB
TIMM17A
Tbio
Family:  Enzyme
Novelty:  0.02095904
Score:  0.994
Data Source:  STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
Score:  0.991
Data Source:  STRINGDB
TIMM21
Tbio
Family:  Enzyme
Novelty:  0.05431101
Score:  0.987
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.985
Data Source:  STRINGDB
Publication Statistics
PubMed Score  22.12

PubMed score by year
PubTator Score  18.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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