Tbio FIS1 Mitochondrial fission 1 protein

Protein Summary

Description

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9Y3D6
• Q9BTP3

Gene Name

• FIS1

Ensembl ID

• ENST00000223136
• ENSP00000223136
• ENSG00000214253

Symbol

• TTC11
• TTC11
• CGI-135

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
transcription factor binding site profile	0.8
disease perturbation	0.79
tissue	0.69
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.44   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 332   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.44   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0