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Tdark
MRPS18C
28S ribosomal protein S18c, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295491
  • ENSP00000295491
  • ENSG00000163319

Symbol
  • CGI-134
  • S18mt-c
  • MRPS18-1
  • mrps18-c
  • MRP-S18-1
  • MRP-S18-c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.76
transcription factor binding site profile
0.76
virus perturbation
0.76
cellular component
0.73


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S18C
VGNC:639
461277
Macaque
mitochondrial ribosomal protein S18C
707257
Mouse
MGI:1915985
68735
Rat
RGD:1307997
289469
Horse
mitochondrial ribosomal protein S18C
VGNC:51212
100629889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S18C
Macaque
mitochondrial ribosomal protein S18C
Mouse
Rat
Horse
mitochondrial ribosomal protein S18C
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3D5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Protein-Protein Interactions (211)
1 – 10 of 211
SMG5
Tbio
Novelty: 0.04143189
p_int: 0.9999999
p_ni: 1.9e-8
p_wrong: 8.2e-8
Data Source: BioPlex
NUDT6
Tbio
Novelty: 0.03648851
p_int: 0.9999865
p_ni: 0.000006123
p_wrong: 0.000007378
Data Source: BioPlex
MRPS9
Tdark
Novelty: 0.22906484
p_int: 0.999576534
p_ni: 0.000423466
Score: 0.996
Data Source: BioPlex,STRINGDB
NOA1
Tbio
Novelty: 0.01478325
p_int: 0.999117803
p_ni: 0.000882095
p_wrong: 1.02e-7
Data Source: BioPlex
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.997920004
p_ni: 0.002079996
Score: 0.993
Data Source: BioPlex,STRINGDB
EDC4
Tbio
Novelty: 0.00365253
p_int: 0.997564023
p_ni: 0.002435977
Data Source: BioPlex
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.997273856
p_ni: 0.002726144
Score: 0.998
Data Source: BioPlex,STRINGDB
DAP3
Tbio
Novelty: 0.05551866
p_int: 0.997246174
p_ni: 0.002753826
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPS28
Tdark
Novelty: 0.58823529
p_int: 0.997091627
p_ni: 0.002908373
Score: 0.983
Data Source: BioPlex,STRINGDB
MRPS33
Tdark
Novelty: 0.27300643
p_int: 0.996310474
p_ni: 0.003689526
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.14

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer