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Tbio
MRPS16
28S ribosomal protein S16, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372945
  • ENSP00000362036
  • ENSG00000182180

Symbol
  • RPMS16
  • COXPD2
  • RPMS16
  • CGI-132
  • MRP-S16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.89
interacting protein
0.84
transcription factor binding site profile
0.79
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (290)
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.993237672
p_ni:  0.006762328
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.954142008
p_ni:  0.045857992
Score:  0.992
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.945326006
p_ni:  0.054673994
Score:  0.994
Data Source:  BioPlex,STRINGDB
MRPS27
Tbio
Novelty:  0.22058227
p_int:  0.929990773
p_ni:  0.070009227
Score:  0.993
Data Source:  BioPlex,STRINGDB
TRMT10B
Tdark
Family:  Enzyme
Novelty:  0.61950381
p_int:  0.928734849
p_ni:  0.071265151
Score:  0.72
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.878493161
p_ni:  0.121506059
p_wrong:  7.81e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.840300623
p_ni:  0.159699377
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPL43
Tdark
Novelty:  0.22331841
Score:  0.999
Data Source:  STRINGDB
MRPL11
Tbio
Novelty:  0.1320634
Score:  0.999
Data Source:  STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
50.6
body height
1
1
1
45.7
reticulocyte measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
50.6
body height
1
45.7
reticulocyte measurement
1
35
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S16
VGNC:4824
450894
Macaque
mitochondrial ribosomal protein S16 [Source:HGNC Symbol;Acc:HGNC:14048]
Mouse
MGI:1913492
66242
Rat
RGD:1582995
688912
Dog
mitochondrial ribosomal protein S16
609906
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S16
Macaque
mitochondrial ribosomal protein S16 [Source:HGNC Symbol;Acc:HGNC:14048]
Mouse
Rat
Dog
mitochondrial ribosomal protein S16
Publication Statistics
PubMed Score 3.37
PubMed score by year
PubTator Score 2.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title