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Tbio
MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

Protein Summary
Description
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376510
  • ENSP00000365693
  • ENSG00000148450

Symbol
  • CBS-1
  • MSRB
  • CBS1
  • MSRB
  • PILB
  • CBS-1
  • CGI-131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
gene perturbation
0.86
disease perturbation
0.74
tissue sample
0.62
cell line
0.6


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.85   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.85   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methionine sulfoxide reductase B2
VGNC:53395
741095
Macaque
methionine sulfoxide reductase B2
711305
Mouse
MGI:1923717
76467
Rat
RGD:1306026
361286
Dog
methionine sulfoxide reductase B2
VGNC:43450
608357
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methionine sulfoxide reductase B2
Macaque
methionine sulfoxide reductase B2
Mouse
Rat
Dog
methionine sulfoxide reductase B2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y3D2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Protein repair
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Protein repair
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
HGNC
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (39)
1 – 10 of 39
UHRF1BP1L
Tbio
Novelty: 0.55650495
p_int: 0.999999973
p_ni: 2.7e-8
Data Source: BioPlex
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.999885527
p_ni: 0.000114061
p_wrong: 4.12e-7
Data Source: BioPlex
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.990839034
p_ni: 0.009160966
Data Source: BioPlex
ALDH5A1
Tclin
Family: Enzyme
Novelty: 0.00461791
p_int: 0.989109217
p_ni: 0.010890783
Data Source: BioPlex
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.963272014
p_ni: 0.036306894
p_wrong: 0.000421092
Data Source: BioPlex
PCBP3
Tbio
Novelty: 0.11681812
p_int: 0.760026697
p_ni: 0.23899578
p_wrong: 0.000977523
Data Source: BioPlex
MSRA
Tbio
Family: Enzyme
Novelty: 0.00595154
Score: 0.993
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.967
Data Source: Reactome,STRINGDB
CBS
Tchem
Family: Enzyme
Novelty: 0.00063091
Score: 0.732
Data Source: STRINGDB
CBSL
Tdark
Novelty: 0.00062189
Score: 0.732
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.85

PubMed score by year
PubTator Score  67.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer