Tbio MSRB2 Methionine-R-sulfoxide reductase B2, mitochondrial

Protein Summary

Description

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.

Uniprot Accession IDs

• Q9Y3D2
• Q17R44
• Q4G1C7
• Q9Y5W6
• MsrB2

Gene Name

• MSRB2

Ensembl ID

• ENST00000376510
• ENSP00000365693
• ENSG00000148450

Symbol

• CBS-1
• MSRB
• CBS1
• MSRB
• PILB
• CBS-1
• CGI-131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
gene perturbation	0.86
disease perturbation	0.74
tissue sample	0.62
cell line	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.28   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.28   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0