Tbio MED31 Mediator of RNA polymerase II transcription subunit 31

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Uniprot Accession IDs

• Q9Y3C7
• B2R4L9

Gene Name

• MED31

Ensembl ID

• ENST00000225728
• ENSP00000225728
• ENSG00000108590

Symbol

• SOH1
• Soh1
• CGI-125
• 3110004H13Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
hub protein	0.79
histone modification site profile	0.77
virus perturbation	0.76
transcription factor binding site profile	0.6

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Mediator Of Rna Polymerase Ii Transcription Subunit 31

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Mediator Of Rna Polymerase Ii Transcription Subunit 31

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.94   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.94   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0