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Tbio
PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373699
  • ENSP00000362803
  • ENSG00000137168

Symbol
  • CYPL1
  • CYPL1
  • hCyPX
  • PPIase
  • CGI-124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
transcription factor binding site profile
0.87
histone modification site profile
0.81
kinase perturbation
0.76
microRNA
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
GPALPP1
Tdark
Novelty:  13.22858591
p_int:  0.999999423
p_ni:  5.76e-7
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
p_int:  0.98751981
p_ni:  0.01248019
Score:  0.431
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.950815395
p_ni:  0.049184605
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPF
Tbio
Novelty:  0.17624854
Score:  0.999
Data Source:  STRINGDB
RBM8A
Tbio
Novelty:  0.00052175
Score:  0.998
Data Source:  STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
Score:  0.998
Data Source:  STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
Score:  0.998
Data Source:  STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
Score:  0.998
Data Source:  STRINGDB
CDC40
Tbio
Novelty:  0.03139044
Score:  0.998
Data Source:  STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
74
heart rate variability measurement
3
1
6
63.6
mean platelet volume
1
1
1
30.9
1
1
0
1.1
30.2
basophil percentage of leukocytes
1
1
1
27.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
74
heart rate variability measurement
6
63.6
mean platelet volume
1
30.9
0
1.1
30.2
basophil percentage of leukocytes
1
27.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 1
VGNC:3664
462652
Mouse
MGI:1916066
68816
Rat
RGD:1309119
309651
Dog
peptidylprolyl isomerase like 1
VGNC:44855
474891
Horse
peptidylprolyl isomerase like 1
VGNC:21734
100053792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 1
Mouse
Rat
Dog
peptidylprolyl isomerase like 1
Horse
peptidylprolyl isomerase like 1
Publication Statistics
PubMed Score 14.23
PubMed score by year
PubTator Score 79.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title