Tbio TPRKB EKC/KEOPS complex subunit TPRKB

Protein Summary

Description

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).

Uniprot Accession IDs

• Q9Y3C4
• D6W5H6
• Q8IWR6
• Q8IWR7
• Q9H3K4

Gene Name

• TPRKB

Ensembl ID

• ENST00000272424
• ENSP00000272424
• ENSG00000144034
• ENST00000318190
• ENSP00000325398
• ENST00000409716
• ENSP00000386936

Symbol

• CGI121
• GAMOS5
• CGI-121

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.92
transcription factor binding site profile	0.84
virus perturbation	0.79
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.37   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.37   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0