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Tbio
TPRKB
EKC/KEOPS complex subunit TPRKB

Protein Summary
Description
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272424
  • ENSP00000272424
  • ENSG00000144034
  • ENST00000318190
  • ENSP00000325398
  • ENST00000409716
  • ENSP00000386936

Symbol
  • CGI121
  • GAMOS5
  • CGI-121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.92
transcription factor binding site profile
0.84
virus perturbation
0.79
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.47   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.47   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (52)
1 – 10 of 52
OSGEP
Tbio
Family: Enzyme
Novelty: 0.01348632
p_int: 0.999995848
p_ni: 0.000004152
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LAGE3
Tdark
Novelty: 0.03704357
p_int: 0.999995513
p_ni: 0.000004484
p_wrong: 3e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
TP53RK
Tbio
Family: Kinase
Novelty: 0.06549878
p_int: 0.999936474
p_ni: 0.000063526
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NUP43
Tdark
Novelty: 0.35294118
p_int: 0.999917847
p_ni: 0.000082153
Score: 0.757
Data Source: BioPlex,STRINGDB
GORASP1
Tbio
Novelty: 0.0271696
p_int: 0.996480736
p_ni: 0.003519263
p_wrong: 1e-9
Data Source: BioPlex
CCDC28A
Tdark
Novelty: 0.72
p_int: 0.989632758
p_ni: 0.00913304
p_wrong: 0.001234202
Data Source: BioPlex
MBIP
Tbio
Novelty: 0.10438201
p_int: 0.987503681
p_ni: 0.012485966
p_wrong: 0.000010353
Score: 0.656
Data Source: BioPlex,STRINGDB
COMMD10
Tdark
Novelty: 0.26481715
p_int: 0.88874641
p_ni: 0.087364065
p_wrong: 0.023889526
Score: 0.718
Data Source: BioPlex,STRINGDB
GATD1
Tdark
Family: Enzyme
Novelty: 1
p_int: 0.76966542
p_ni: 0.230333258
p_wrong: 0.000001322
Data Source: BioPlex
GON7
Tdark
Novelty: 0.38426349
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.47

PubMed score by year
PubTator Score  3.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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