Tbio NOP16 Nucleolar protein 16

Protein Summary

Description

This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9Y3C1
• B4DV13
• D6RGD3
• Q05D05
• Q6IAI6
• Q6PIM0
• Q8IXL5

Gene Name

• NOP16

Ensembl ID

• ENST00000614830
• ENSP00000480832
• ENSG00000048162
• ENST00000618911
• ENSP00000483001

Symbol

• HSPC111
• HSPC185

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor perturbation	0.91
histone modification site profile	0.89
disease perturbation	0.87
interacting protein	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.62   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.62   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0