Tdark RRP15 RRP15-like protein

Protein Summary

Description

This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y3B9

Gene Name

• RRP15

Ensembl ID

• ENST00000366932
• ENSP00000355899
• ENSG00000067533

Symbol

• KIAA0507
• CGI-115
• KIAA0507

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
transcription factor binding site profile	0.9
transcription factor perturbation	0.88
microRNA	0.84
kinase perturbation	0.81

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.85   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.85   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (2)

Components (1)

Processes (1)

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GO Term	Evidence	Assigned by
preribosome, large subunit precursor	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (237)

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1 – 10 of 237

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PPAN

Tbio

Novelty: 0.0010549

p_int: 0.982660904

p_ni: 0.017339096

Score: 0.975

Data Source: BioPlex,STRINGDB

WDR46

Tdark

Novelty: 0.36421448

p_int: 0.88293889

p_ni: 0.11706111

Score: 0.903

Data Source: BioPlex,STRINGDB

RPL11

Tbio

Novelty: 0.00566877

p_int: 0.84651705

p_ni: 0.15348295

Score: 0.283

Data Source: BioPlex,STRINGDB

NIFK

Tbio

Novelty: 0.02038052

Score: 0.996

Data Source: STRINGDB

SURF6

Tbio

Novelty: 0.06528836

Score: 0.991

Data Source: STRINGDB

RPF2

Tbio

Novelty: 0.08174387

Score: 0.991

Data Source: STRINGDB

RRS1

Tbio

Novelty: 0.00929224

Score: 0.99

Data Source: STRINGDB

RBM28

Tbio

Novelty: 0.01991731

Score: 0.987

Data Source: STRINGDB

WDR74

Tbio

Novelty: 0.10605391

Score: 0.987

Data Source: STRINGDB

RPF1

Tdark

Novelty: 8

Score: 0.985

Data Source: STRINGDB

Publication Statistics

PubMed Score  1.85

PubMed score by year

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PubTator Score  1.05

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Citrullination
Coiled coil
Complete proteome
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

BMI-adjusted waist circumference
body height
central corneal thickness
cup-to-disc ratio measurement
diastolic blood pressure
FEV/FEC ratio
heel bone mineral density
intraocular pressure measurement
physical activity measurement
smoking behavior