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Tbio
REXO2
Oligoribonuclease, mitochondrial

Protein Summary
Description
3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling. This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265881
  • ENSP00000265881
  • ENSG00000076043
  • ENST00000611665
  • ENSP00000480535

Symbol
  • SFN
  • SMFN
  • RFN
  • SFN
  • REX2
  • CGI-114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
virus perturbation
0.99
disease perturbation
0.93
cellular component
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.76   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.76   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (77)
1 – 10 of 77
REXO1
Tdark
Family: Enzyme
Novelty: 0.23817911
Score: 0.964
Data Source: STRINGDB
REXO5
Tdark
Family: Enzyme
Novelty: 0.8782494
Score: 0.904
Data Source: STRINGDB
REXO4
Tbio
Family: Enzyme
Novelty: 0.0328295
Score: 0.83
Data Source: STRINGDB
NHP2
Tbio
Novelty: 0.01414024
Score: 0.789
Data Source: STRINGDB
EXO1
Tbio
Family: Enzyme
Novelty: 0.00130104
Score: 0.764
Data Source: STRINGDB
ELAC2
Tbio
Family: Enzyme
Novelty: 0.01234318
Score: 0.754
Data Source: STRINGDB
SSBP1
Tbio
Novelty: 0.01105839
Score: 0.747
Data Source: STRINGDB
LRFN3
Tdark
Novelty: 0.30018245
Score: 0.703
Data Source: STRINGDB
POLR2L
Tbio
Family: Enzyme
Novelty: 0.03847579
Score: 0.702
Data Source: STRINGDB
POLR2I
Tbio
Family: Enzyme
Novelty: 0.03100605
Score: 0.688
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.76

PubMed score by year
PubTator Score  262.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer