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Tbio
MRPL11
39S ribosomal protein L11, mitochondrial

Protein Summary
Description
This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310999
  • ENSP00000308897
  • ENSG00000174547
  • ENST00000329819
  • ENSP00000329630
  • ENST00000430466
  • ENSP00000415356

Symbol
  • L11MT
  • CGI-113
  • MRP-L11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.96
histone modification site profile
0.91
disease perturbation
0.87
transcription factor binding site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
26.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
26.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L11
VGNC:1107
466677
Macaque
mitochondrial ribosomal protein L11
714094
Mouse
MGI:2137215
66419
Rat
RGD:1359665
293666
Dog
mitochondrial ribosomal protein L11
VGNC:43377
476012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L11
Macaque
mitochondrial ribosomal protein L11
Mouse
Rat
Dog
mitochondrial ribosomal protein L11
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y3B7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (360)
1 – 10 of 360
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.999336107
p_ni: 0.000663893
Score: 0.989
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999137879
p_ni: 0.000862121
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.998679108
p_ni: 0.001320892
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.997264549
p_ni: 0.002735451
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.996622512
p_ni: 0.003377488
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.996350381
p_ni: 0.003649619
Score: 0.989
Data Source: BioPlex,STRINGDB
RPL37
Tbio
Novelty: 0.03935854
p_int: 0.994986673
p_ni: 0.005013327
Score: 0.505
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.994199784
p_ni: 0.005800216
Score: 0.983
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.994112337
p_ni: 0.005887663
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.986290503
p_ni: 0.013709497
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.43

PubMed score by year
PubTator Score  2.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer