SF3B6
Splicing factor 3B subunit 6
Protein Summary
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PubMed:16432215). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215). This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts dir ...more
- ENST00000233468
- ENSP00000233468
- ENSG00000115128
- SAP14
- SF3B14
- SF3B14A
- P14
- Ht006
- SAP14
- SAP14a
- SF3B14
- CGI-110
- HSPC175
- SF3B14a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.9 | ||
small molecule perturbation | 0.81 | ||
histone modification site profile | 0.77 | ||
transcription factor | 0.7 | ||
transcription factor binding site profile | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.91 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.91 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (260)
PHF5A
Family: Epigenetic
Novelty: 0.02989472
p_int: 0.99379557
p_ni: 0.00620443
Score: 0.994
Data Source: BioPlex,STRINGDB
CCDC97
Novelty: 2.36351796
p_int: 0.977993402
p_ni: 0.022006598
Score: 0.998
Data Source: BioPlex,STRINGDB
SNRPE
Novelty: 0.02033423
p_int: 0.867355641
p_ni: 0.132644359
Score: 0.98
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | mRNA Splicing | ||||
Reactome | mRNA Splicing - Major Pathway | ||||
Reactome | mRNA Splicing - Minor Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
mRNA Splicing | ||||
mRNA Splicing - Major Pathway | ||||
mRNA Splicing - Minor Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 5 | 8 | 98.6 | |||||
reticulocyte count | 7 | 4 | 13 | 97.4 | |||||
lymphocyte count | 2 | 3 | 3 | 96.6 | |||||
mean corpuscular volume | 1 | 3 | 3 | 94.9 | |||||
lymphocyte percentage of leukocytes | 2 | 3 | 3 | 86.3 | |||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 8 | 98.6 | |||||
reticulocyte count | 13 | 97.4 | |||||
lymphocyte count | 3 | 96.6 | |||||
mean corpuscular volume | 3 | 94.9 | |||||
lymphocyte percentage of leukocytes | 3 | 86.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | splicing factor 3b subunit 6 | VGNC:6398 | 459061 | |||||
Macaque | splicing factor 3b subunit 6 | 704090 | ||||||
Mouse | MGI:1913305 | 66055 | ||||||
Dog | splicing factor 3b subunit 6 | VGNC:46074 | 475682 | |||||
Horse | splicing factor 3b subunit 6 | VGNC:22893 | 100056247 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | splicing factor 3b subunit 6 | |||||
Macaque | splicing factor 3b subunit 6 | |||||
Mouse | ||||||
Dog | splicing factor 3b subunit 6 | |||||
Horse | splicing factor 3b subunit 6 | |||||
Publication Statistics
PubMed Score 7.91
PubMed score by year
PubTator Score 2.68
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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