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Tdark
TMED7
Transmembrane emp24 domain-containing protein 7

Protein Summary
Description
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000456936
  • ENSP00000405926
  • ENSG00000134970

Symbol
  • p27
  • p24g3
  • CGI-109
  • p24gamma3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
microRNA
0.84
cell type or tissue
0.79
disease perturbation
0.68
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
3.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 7
VGNC:53275
471605
Mouse
MGI:1913926
66676
Rat
RGD:727954
252889
Horse
transmembrane p24 trafficking protein 7
100529263
Cow
transmembrane p24 trafficking protein 7
100125926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 7
Mouse
Rat
Horse
transmembrane p24 trafficking protein 7
Cow
transmembrane p24 trafficking protein 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y3B3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (74)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (15)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (236)
1 – 10 of 236
BLZF1
Tbio
Novelty: 0.04344183
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.605
Data Source: BioPlex,STRINGDB
TMED4
Tdark
Novelty: 0.22372593
p_int: 0.999994302
p_ni: 0.000005697
p_wrong: 1e-9
Score: 0.465
Data Source: BioPlex,STRINGDB
HECW2
Tbio
Family: Enzyme
Novelty: 0.07194044
p_int: 0.999925707
p_ni: 0.000074293
Data Source: BioPlex
TMED2
Tbio
Novelty: 0.03731104
p_int: 0.999905695
p_ni: 0.000094305
Score: 0.969
Data Source: BioPlex,STRINGDB
TP53I13
Tdark
Novelty: 0.72502189
p_int: 0.999841361
p_ni: 0.000028323
p_wrong: 0.000130316
Data Source: BioPlex
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.999829166
p_ni: 0.000169571
p_wrong: 0.000001263
Data Source: BioPlex
TMED9
Tdark
Novelty: 0.24024246
p_int: 0.999826387
p_ni: 0.000173613
Score: 0.96
Data Source: BioPlex,STRINGDB
WNT11
Tbio
Novelty: 0.0045754
p_int: 0.999621162
p_ni: 0.000246087
p_wrong: 0.000132751
Data Source: BioPlex
CIZ1
Tbio
Novelty: 0.03730538
p_int: 0.999157844
p_ni: 0.000842152
p_wrong: 4e-9
Data Source: BioPlex
ELMOD1
Tbio
Novelty: 0.28255275
p_int: 0.999150424
p_ni: 3e-9
p_wrong: 0.000849573
Data Source: BioPlex
Publication Statistics
PubMed Score  3.10

PubMed score by year
PubTator Score  14.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer