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Tbio
UBE2J1
Ubiquitin-conjugating enzyme E2 J1

Protein Summary
Description
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435041
  • ENSP00000451261
  • ENSG00000198833

Symbol
  • NCUBE1
  • UBC6
  • UBC6E
  • Ubc6p
  • CGI-76
  • NCUBE1
  • HSPC153
  • HSPC205
  • NCUBE-1
  • HSU93243
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.96
transcription factor perturbation
0.96
disease perturbation
0.83
PubMedID
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
68.1
urate measurement
2
2
2
49.2
creatinine measurement
1
1
1
30.2
diabetic nephropathy
1
1
0
1.3
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
68.1
urate measurement
2
49.2
creatinine measurement
1
30.2
diabetic nephropathy
0
1.3
0.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 J1
VGNC:8609
462883
Mouse
MGI:1926245
56228
Rat
RGD:1305067
297961
Dog
ubiquitin conjugating enzyme E2 J1
VGNC:48055
474993
Horse
ubiquitin conjugating enzyme E2 J1
VGNC:24721
100071009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 J1
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 J1
Horse
ubiquitin conjugating enzyme E2 J1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y385-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (329)
1 – 10 of 329
NME2P1
Tdark
Family:  Kinase
p_int:  0.980409502
p_ni:  0.019590496
p_wrong:  2e-9
Data Source:  BioPlex
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
p_int:  0.869051305
p_ni:  0.130948666
p_wrong:  3e-8
Score:  0.39
Data Source:  BioPlex,STRINGDB
UBE2H
Tbio
Novelty:  0.03259425
Score:  0.972
Data Source:  STRINGDB
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
Score:  0.97
Data Source:  STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.97
Data Source:  STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.965
Data Source:  STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
Score:  0.962
Data Source:  STRINGDB
UBA1
Tbio
Novelty:  0.00419724
Score:  0.957
Data Source:  STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.955
Data Source:  STRINGDB
UBA6
Tchem
Novelty:  0.05213412
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  25.75

PubMed score by year
PubTator Score  13.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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