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Tdark
LUC7L2
Putative RNA-binding protein Luc7-like 2

Protein Summary
Description
May bind to RNA via its Arg/Ser-rich domain. This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263545
  • ENSP00000263545
  • ENSG00000146963
  • ENST00000354926
  • ENSP00000347005
  • ENST00000541170
  • ENSP00000441604
  • ENST00000619796
  • ENSP00000483438

Symbol
  • CGI-59
  • CGI-74
  • LUC7B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.99
disease perturbation
0.95
kinase perturbation
0.93
virus perturbation
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.12   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (142)
1 – 10 of 142
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.999999901
p_ni:  9.9e-8
Data Source:  BioPlex
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999999877
p_ni:  1.23e-7
Score:  0.361
Data Source:  BioPlex,STRINGDB
GPATCH8
Tdark
Novelty:  0.45717416
p_int:  0.999999083
p_ni:  9.17e-7
Data Source:  BioPlex
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.999991411
p_ni:  0.000008589
Data Source:  BioPlex
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.999976794
p_ni:  0.000023205
p_wrong:  1e-9
Data Source:  BioPlex
ZRANB2
Tbio
Novelty:  0.06105086
p_int:  0.999892775
p_ni:  0.000107225
Data Source:  BioPlex
PAIP2B
Tbio
Novelty:  0.65592664
p_int:  0.999720092
p_ni:  0.000279908
Data Source:  BioPlex
RNPS1
Tbio
Novelty:  0.03203224
p_int:  0.999667499
p_ni:  0.000332501
Score:  0.198
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.999606691
p_ni:  0.000393309
Score:  0.271
Data Source:  BioPlex,STRINGDB
SRSF12
Tbio
Novelty:  0.34992606
p_int:  0.99951017
p_ni:  0.000489827
p_wrong:  3e-9
Score:  0.307
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular diastolic function measurement
1
1
0
1.7
21.5
high density lipoprotein cholesterol measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular diastolic function measurement
0
1.7
21.5
high density lipoprotein cholesterol measurement
1
17.8
Publication Statistics
PubMed Score 4.12
PubMed score by year
PubTator Score 2.91
PubTator score by year