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Tbio
CAB39
Calcium-binding protein 39

Protein Summary
Description
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258418
  • ENSP00000258418
  • ENSG00000135932
  • ENST00000409788
  • ENSP00000386238
  • ENST00000410084
  • ENSP00000386642

Symbol
  • MO25
  • MO25
  • CGI-66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
interacting protein
0.92
biological process
0.85
transcription factor binding site profile
0.82
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.97   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.97   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
CAB39L
Tbio
Novelty:  0.15875148
p_int:  0.999999954
p_ni:  4.5e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
STRADB
Tbio
Family:  Kinase
Novelty:  0.03532206
p_int:  0.999999715
p_ni:  4e-9
p_wrong:  2.81e-7
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
STK25
Tchem
Family:  Kinase
Novelty:  0.03229688
p_int:  0.999993891
p_ni:  0.000006109
Score:  0.904
Data Source:  BioPlex,STRINGDB
STK11
Tchem
Family:  Kinase
Novelty:  0.00073247
p_int:  0.999801199
p_ni:  0.000198801
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999427628
p_ni:  0.000572372
Score:  0.196
Data Source:  BioPlex,STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.999077255
p_ni:  0.000922745
Score:  0.54
Data Source:  BioPlex,STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.939230218
p_ni:  0.06076977
p_wrong:  1.2e-8
Score:  0.331
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.899157528
p_ni:  0.100716287
p_wrong:  0.000126185
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.861867261
p_ni:  0.138132698
p_wrong:  4.1e-8
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.786140771
p_ni:  0.21382067
p_wrong:  0.000038559
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (47)
Energy dependent regulation of mTOR by LKB1-AMPK (R-HSA-380972)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Energy dependent regulation of mTOR by LKB1-AMPK
Immune System
Innate Immune System
Neutrophil degranulation
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
54.4
mean corpuscular volume
1
1
1
46.1
mean reticulocyte volume
1
1
1
35
lymphocyte count
2
1
2
24.3
lymphocyte percentage of leukocytes
1
1
1
11
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
54.4
mean corpuscular volume
1
46.1
mean reticulocyte volume
1
35
lymphocyte count
2
24.3
lymphocyte percentage of leukocytes
1
11
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium binding protein 39
VGNC:115
470672
Macaque
calcium binding protein 39
711166
Mouse
MGI:107438
12283
Dog
calcium binding protein 39
VGNC:38619
477403
Horse
calcium binding protein 39
VGNC:15970
100063745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium binding protein 39
Macaque
calcium binding protein 39
Mouse
Dog
calcium binding protein 39
Horse
calcium binding protein 39
Publication Statistics
PubMed Score 58.97
PubMed score by year
PubTator Score 22.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title