Tbio CAB39 Calcium-binding protein 39

Protein Summary

Description

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Uniprot Accession IDs

• Q9Y376
• A8K8L7

Gene Name

• CAB39

Ensembl ID

• ENST00000258418
• ENSP00000258418
• ENSG00000135932
• ENST00000409788
• ENSP00000386238
• ENST00000410084
• ENSP00000386642

Symbol

• MO25
• MO25
• CGI-66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
interacting protein	0.92
biological process	0.85
transcription factor binding site profile	0.82
microRNA	0.74

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Annexin / Calcium-binding Protein 39

DTO Classes

Protein / Calcium-binding Protein / Annexin / Calcium-binding Protein 39

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.5   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.5   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0