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Tchem
SLC6A5
Sodium- and chloride-dependent glycine transporter 2

Protein Summary
Description
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000525748
  • ENSP00000434364
  • ENSG00000165970

Symbol
  • GLYT2
  • NET1
  • NET1
  • GLYT2
  • HKPX3
  • GLYT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
cell type or tissue
0.74
cell line
0.61
PubMedID
0.56
transcription factor
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.66   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.66   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 59
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (59)
1 – 10 of 59
CHEMBL239603
chemical structure image
CHEMBL392350
chemical structure image
CHEMBL393168
chemical structure image
CHEMBL239605
chemical structure image
CHEMBL394236
chemical structure image
CHEMBL239601
chemical structure image
bitopertin
chemical structure image
CHEMBL524135
chemical structure image
CHEMBL88588
chemical structure image
CHEMBL3325497
chemical structure image
Pathways (65)
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) (R-HSA-5619089)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Disease
Disorders of transmembrane transporters
Na+/Cl- dependent neurotransmitter transporters
SLC transporter disorders
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (57)
1 – 10 of 57
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.99535307
p_ni: 0.00464693
Data Source: BioPlex
GPR89A
Tdark
Family: IC
Novelty: 0.13236179
p_int: 0.974172872
p_ni: 0.025822007
p_wrong: 0.000005121
Data Source: BioPlex
TBC1D24
Tbio
Novelty: 0.01368787
p_int: 0.965425722
p_ni: 0.031052098
p_wrong: 0.00352218
Score: 0.226
Data Source: BioPlex,STRINGDB
ARL6IP5
Tbio
Novelty: 0.01272626
p_int: 0.928759477
p_ni: 0.071240523
Score: 0.313
Data Source: BioPlex,STRINGDB
GNG5
Tbio
Novelty: 0.21523747
p_int: 0.919084625
p_ni: 0.043788259
p_wrong: 0.037127116
Score: 0.547
Data Source: BioPlex,STRINGDB
ATP5PB
Tbio
Family: Enzyme
Novelty: 0.16134052
p_int: 0.918512275
p_ni: 0.081487725
Score: 0.55
Data Source: BioPlex,STRINGDB
GOLGA5
Tbio
Novelty: 0.07430341
p_int: 0.853853249
p_ni: 0.146146751
Data Source: BioPlex
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.02087315
p_int: 0.817207554
p_ni: 0.182792446
Score: 0.243
Data Source: BioPlex,STRINGDB
RETREG3
Tdark
Novelty: 1.68674699
p_int: 0.781170301
p_ni: 0.218829683
p_wrong: 1.7e-8
Score: 0.656
Data Source: BioPlex,STRINGDB
NAT14
Tbio
Family: Enzyme
Novelty: 0.1
p_int: 0.760528253
p_ni: 0.239471743
p_wrong: 4e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  208.66

PubMed score by year
PubTator Score  32.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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