Tbio LSM2 U6 snRNA-associated Sm-like protein LSm2

Protein Summary

Description

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q9Y333
• Q6FGG1

Gene Name

• LSM2

Ensembl ID

• ENST00000375661
• ENSP00000364813
• ENSG00000204392
• ENST00000383391
• ENSP00000372883
• ENSG00000172850
• ENST00000424975
• ENSP00000403345
• ENSG00000231502
• ENST00000432122
• ENSP00000414006
• ENSG00000224979
• ENST00000434125
• ENSP00000406280
• ENSG00000225998
• ENST00000455705
• ENSP00000414634
• ENSG00000236826

Symbol

• C6orf28
• G7B
• G7B
• snRNP
• C6orf28
• YBL026W

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
co-expressed gene	0.97
kinase perturbation	0.93
disease perturbation	0.83
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / U6 Snrna-associated Sm-like Protein Lsm2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / U6 Snrna-associated Sm-like Protein Lsm2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.15   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.15   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0