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Tbio
TMX2
Thioredoxin-related transmembrane protein 2

Protein Summary
Description
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278422
  • ENSP00000278422
  • ENSG00000213593
  • ENST00000378312
  • ENSP00000367562

Symbol
  • TXNDC14
  • PIG26
  • CGI-31
  • PDIA12
  • TXNDC14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
histone modification site profile
0.92
gene perturbation
0.85
kinase perturbation
0.84
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
94.9
self reported educational attainment
1
1
1
89.4
wellbeing measurement
1
1
1
68.3
2
1
0
1.1
30.7
alcohol use disorder measurement
1
1
0
5.7
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
94.9
self reported educational attainment
1
89.4
wellbeing measurement
1
68.3
0
1.1
30.7
alcohol use disorder measurement
0
5.7
24.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (24)
1 – 10 of 24
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.997064689
p_ni: 0.002935299
p_wrong: 1.2e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
CNGA3
Tchem
Family: IC
Novelty: 0.00818181
p_int: 0.98953766
p_ni: 0.01046234
Data Source: BioPlex
SRPRB
Tbio
Novelty: 0.04735362
p_int: 0.982789515
p_ni: 0.01720865
p_wrong: 0.000001835
Data Source: BioPlex
SLC4A8
Tbio
Family: Transporter
Novelty: 0.01606111
p_int: 0.923775305
p_ni: 0.076224551
p_wrong: 1.44e-7
Data Source: BioPlex
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.91466436
p_ni: 0.085315672
p_wrong: 0.000019968
Data Source: BioPlex
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.862969046
p_ni: 0.137029482
p_wrong: 0.000001471
Score: 0.193
Data Source: BioPlex,STRINGDB
PTH1R
Tclin
Family: GPCR
Novelty: 0.00413989
p_int: 0.855453203
p_ni: 0.144546797
Data Source: BioPlex
TMEM63C
Tdark
Family: IC
Novelty: 0.02849254
p_int: 0.840175988
p_ni: 0.159823923
p_wrong: 8.9e-8
Data Source: BioPlex
ASIC4
Tbio
Family: IC
Novelty: 0.02912816
p_int: 0.828243319
p_ni: 0.171739347
p_wrong: 0.000017334
Data Source: BioPlex
KCNK16
Tbio
Family: IC
Novelty: 0.09168043
p_int: 0.820791553
p_ni: 0.179130031
p_wrong: 0.000078416
Score: 0.363
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.73

PubMed score by year
PubTator Score  8.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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