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Tbio
DERA
Deoxyribose-phosphate aldolase

Protein Classes
Protein Summary
Description
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428559
  • ENSP00000416583
  • ENSG00000023697

Symbol
  • DEOC
  • CGI-26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.91
histone modification site profile
0.86
kinase perturbation
0.84
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.56   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.56   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
61.5
self reported educational attainment
1
1
1
54.7
mathematical ability
1
1
1
54.7
1
1
0
2.2
34.2
stressful life event measurement
1
1
0
2.4
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
61.5
self reported educational attainment
1
54.7
mathematical ability
1
54.7
0
2.2
34.2
stressful life event measurement
0
2.4
4.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxyribose-phosphate aldolase
VGNC:8399
465316
Macaque
deoxyribose-phosphate aldolase
701427
Mouse
MGI:1913762
232449
Rat
RGD:1589836
690945
Dog
deoxyribose-phosphate aldolase
VGNC:39901
477684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxyribose-phosphate aldolase
Macaque
deoxyribose-phosphate aldolase
Mouse
Rat
Dog
deoxyribose-phosphate aldolase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y315-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of carbohydrates
Neutrophil degranulation
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (106)
1 – 10 of 106
PCMT1
Tbio
Family: Enzyme
Novelty: 0.01414946
p_int: 0.999999501
p_ni: 4.99e-7
Score: 0.254
Data Source: BioPlex,STRINGDB
LANCL1
Tbio
Novelty: 0.06479031
p_int: 0.999996225
p_ni: 0.000003775
Score: 0.226
Data Source: BioPlex,STRINGDB
TLR1
Tbio
Novelty: 0.00171909
p_int: 0.999879482
p_ni: 0.000120515
p_wrong: 4e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
ERP29
Tbio
Novelty: 0.0132632
p_int: 0.999558238
p_ni: 0.000441762
Score: 0.345
Data Source: BioPlex,STRINGDB
PPIL1
Tbio
Family: Enzyme
Novelty: 0.08004386
p_int: 0.98751981
p_ni: 0.01248019
Score: 0.431
Data Source: BioPlex,STRINGDB
RBKS
Tbio
Family: Kinase
Novelty: 0.01660806
Score: 0.969
Data Source: STRINGDB
PGM2
Tbio
Family: Enzyme
Novelty: 0.00922421
Score: 0.968
Data Source: STRINGDB
TKTL2
Tbio
Family: Enzyme
Novelty: 0.0915871
Score: 0.958
Data Source: STRINGDB
ALDH16A1
Tdark
Family: Enzyme
Novelty: 0.21880567
Score: 0.951
Data Source: STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00208619
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.56

PubMed score by year
PubTator Score  53.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer