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Tbio
AAR2
Protein AAR2 homolog

Protein Summary
Description
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320849
  • ENSP00000313674
  • ENSG00000131043
  • ENST00000373932
  • ENSP00000363043

Symbol
  • C20orf4
  • CGI-23
  • C20orf4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.85
transcription factor binding site profile
0.78
cell type or tissue
0.69
hub protein
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.09   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.09   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
86.7
appendicular lean mass
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
86.7
appendicular lean mass
1
22.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AAR2 splicing factor homolog
VGNC:9819
458215
Macaque
AAR2 splicing factor homolog
703053
Mouse
MGI:1915545
68295
Rat
RGD:1311066
296312
Dog
AAR2 splicing factor homolog
VGNC:37414
477218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AAR2 splicing factor homolog
Macaque
AAR2 splicing factor homolog
Mouse
Rat
Dog
AAR2 splicing factor homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y312-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ciliary landscape
WikiPathways
Ciliary landscape
WikiPathways
Ciliary landscape
WikiPathways
Ciliary landscape
WikiPathways
Breast cancer pathway
Name
Explore in Pharos
Explore in Source
Ciliary landscape
Ciliary landscape
Ciliary landscape
Ciliary landscape
Breast cancer pathway
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (104)
1 – 10 of 104
EAPP
Tbio
Novelty: 0.06519266
p_int: 0.99999993
p_ni: 7e-8
Score: 0.91
Data Source: BioPlex,STRINGDB
TSSC4
Tdark
Novelty: 0.17064786
p_int: 0.999999929
p_ni: 7.1e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
SLC7A6OS
Tdark
Family: Transporter
Novelty: 0.27600109
p_int: 0.99999809
p_ni: 1.55e-7
p_wrong: 0.000001755
Score: 0.565
Data Source: BioPlex,STRINGDB
ECD
Tbio
Novelty: 0.06070487
p_int: 0.999980036
p_ni: 0.000019964
Score: 0.869
Data Source: BioPlex,STRINGDB
GHDC
Tbio
Novelty: 0.08423152
p_int: 0.999806567
p_ni: 0.000193432
Score: 0.192
Data Source: BioPlex,STRINGDB
KLHL36
Tdark
Novelty: 1.4153425
p_int: 0.999699747
p_ni: 0.000300253
Score: 0.186
Data Source: BioPlex,STRINGDB
ZNHIT2
Tbio
Novelty: 0.13370912
p_int: 0.994708032
p_ni: 0.005291857
p_wrong: 1.11e-7
Score: 0.878
Data Source: BioPlex,STRINGDB
SNRNP200
Tbio
Family: Enzyme
Novelty: 0.01339666
p_int: 0.989812547
p_ni: 0.010187453
Score: 0.984
Data Source: BioPlex,STRINGDB
PRPF8
Tbio
Novelty: 0.01717158
p_int: 0.98600672
p_ni: 0.01399328
Score: 0.995
Data Source: BioPlex,STRINGDB
MICA
Tbio
Novelty: 0.03965901
p_int: 0.967757851
p_ni: 0.030432622
p_wrong: 0.001809527
Data Source: BioPlex
Publication Statistics
PubMed Score  18.09

PubMed score by year
PubTator Score  3.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer