Tbio AAR2 Protein AAR2 homolog

Protein Summary

Description

Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q9Y312
• E1P5S7
• Q9H4F9
• Q9P1P3
• Q9UFK9

Gene Name

• AAR2

Ensembl ID

• ENST00000320849
• ENSP00000313674
• ENSG00000131043
• ENST00000373932
• ENSP00000363043

Symbol

• C20orf4
• CGI-23
• C20orf4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.85
transcription factor binding site profile	0.78
cell type or tissue	0.69
hub protein	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.45   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.45   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0