Tchem AMDHD2 N-acetylglucosamine-6-phosphate deacetylase

Protein Summary

Description

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Uniprot Accession IDs

• Q9Y303
• B4DL77
• Q8WV54
• GlcNAc 6-P deacetylase

Gene Name

• AMDHD2

Ensembl ID

• ENST00000293971
• ENSP00000293971
• ENSG00000162066
• ENST00000302956
• ENSP00000307481
• ENST00000413459
• ENSP00000391596

Symbol

• CGI-14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor binding site profile	0.8
transcription factor	0.7
cell line	0.65
small molecule perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Deacetylase / N-acetylglucosamine-6-phosphate Deacetylase

Protein / ... / Metalloprotease / N-acetylglucosamine-6-phosphate Deacetylase

DTO Classes

Protein / Enzyme / Hydrolase / Deacetylase / N-acetylglucosamine-6-phosphate Deacetylase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.13   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.13   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0