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Tchem
AMDHD2
N-acetylglucosamine-6-phosphate deacetylase

Protein Summary
Description
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293971
  • ENSP00000293971
  • ENSG00000162066
  • ENST00000302956
  • ENSP00000307481
  • ENST00000413459
  • ENSP00000391596

Symbol
  • CGI-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.8
transcription factor
0.7
cell line
0.65
small molecule perturbation
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3219353
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amidohydrolase domain containing 2
VGNC:13659
453838
Macaque
amidohydrolase domain containing 2
697051
Mouse
MGI:2443978
245847
Rat
RGD:1304601
302972
Horse
amidohydrolase domain containing 2
100068441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amidohydrolase domain containing 2
Macaque
amidohydrolase domain containing 2
Mouse
Rat
Horse
amidohydrolase domain containing 2
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Protein-Protein Interactions (32)
1 – 10 of 32
GNPDA1
Tbio
Family: Enzyme
Novelty: 0.01296167
p_int: 0.999999884
p_ni: 9.7e-8
p_wrong: 1.9e-8
Score: 0.816
Data Source: BioPlex,STRINGDB
GNPDA2
Tbio
Family: Enzyme
Novelty: 0.02712908
Score: 0.815
Data Source: STRINGDB
H6PD
Tbio
Novelty: 0.00366637
Score: 0.679
Data Source: STRINGDB
NAGK
Tbio
Family: Kinase
Novelty: 0.01603908
Score: 0.677
Data Source: STRINGDB
GALM
Tbio
Family: Enzyme
Novelty: 0.01067063
Score: 0.643
Data Source: STRINGDB
GFPT2
Tbio
Family: Enzyme
Novelty: 0.01049877
Score: 0.64
Data Source: STRINGDB
GFPT1
Tchem
Family: Enzyme
Novelty: 0.00358283
Score: 0.639
Data Source: STRINGDB
NAGA
Tbio
Family: Enzyme
Novelty: 0.00591296
Score: 0.604
Data Source: STRINGDB
ATP5F1D
Tbio
Family: Enzyme
Novelty: 0.07296539
Score: 0.595
Data Source: STRINGDB
PGM3
Tbio
Family: Enzyme
Novelty: 0.00515842
Score: 0.576
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.22

PubMed score by year
PubTator Score  4.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer