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Tbio
COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

Protein Summary
Description
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334571
  • ENSP00000333946
  • ENSG00000119723
  • ENST00000394026
  • ENSP00000377594

Symbol
  • CGI10
  • CGI-10
  • COQ10D6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
histone modification site profile
0.75
protein domain
0.73
transcription factor perturbation
0.68
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.974288763
p_ni:  0.025326897
p_wrong:  0.000384341
Data Source:  BioPlex
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.95301747
p_ni:  0.04558758
p_wrong:  0.001394951
Score:  0.207
Data Source:  BioPlex,STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
p_int:  0.906978798
p_ni:  0.091756769
p_wrong:  0.001264433
Score:  0.271
Data Source:  BioPlex,STRINGDB
COQ3
Tbio
Family:  Enzyme
Novelty:  0.03013258
Score:  0.997
Data Source:  STRINGDB
COQ2
Tbio
Family:  Enzyme
Novelty:  0.00575853
Score:  0.995
Data Source:  STRINGDB
COQ5
Tbio
Family:  Enzyme
Novelty:  0.04664953
Score:  0.993
Data Source:  STRINGDB
COQ9
Tbio
Novelty:  0.00740475
Score:  0.973
Data Source:  STRINGDB
COQ7
Tbio
Family:  Enzyme
Novelty:  0.01010794
Score:  0.968
Data Source:  STRINGDB
COQ4
Tbio
Novelty:  0.03537017
Score:  0.956
Data Source:  STRINGDB
COQ8B
Tchem
Family:  Kinase
Novelty:  0.02469308
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Ubiquinol biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Ubiquinol biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ganglion cell inner plexiform layer thickness measurement
1
1
1
59
mean corpuscular volume
1
1
1
39.6
mean reticulocyte volume
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ganglion cell inner plexiform layer thickness measurement
1
59
mean corpuscular volume
1
39.6
mean reticulocyte volume
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q6, monooxygenase
VGNC:12617
740390
Macaque
coenzyme Q6, monooxygenase
698047
Mouse
MGI:1924408
217707
Rat
RGD:1311149
299195
Dog
coenzyme Q6, monooxygenase
VGNC:39521
490778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q6, monooxygenase
Macaque
coenzyme Q6, monooxygenase
Mouse
Rat
Dog
coenzyme Q6, monooxygenase
Publication Statistics
PubMed Score 35.61
PubMed score by year
PubTator Score 14.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title